IMMUNOLOGICAL FEATURES OF THE DEVELOPMENT EARLY FORM PERIIMPLANTS AND THE TOPICAL IMMUNOTHERAPY EFFECT ON THE SALIVATOR LEVEL CYTOKINES DURING DENTAL IMPLANTATION

Currently, prosthetics based on dental implants is widely used for the replacement of missing teeth, and consequently the number of complications associated with the occurrence of infl ammation surrounding tissues is growing. The object of the research is to conduct analysis the level oral cytokines in the patients with a closed sinus lift with simultaneous dental implantation, ending in the development of early form of periimplants, and to assess the topical immunotherapy effect on concentration saliva cytokines in this implantation method. 105 patients who received implant treatment were comprehensively examined using laboratory and immunological methods – the dynamics of concentrations of IL-1β, IL-1Ra, IL-8, IL-2 and IL-10 of saliva on the 6th, 12th and 24 th day of the postoperative period was evaluated. Based on the analysis of the salivator level of cytokine in patients with early periimplants the imbalance of the pro- and anti-infl ammatory cytokines of the oral cavity was diagnosed. The topical cytokine therapy with betaleukin and roncoleukin leveled out the revealed immunological changes and prevented the chronic infl ammatory response in the early postoperative period.

dental implantation, closed sinus lift, bone losses periimplants zone, topical immunotherapy, betaleukin, roncoleukin