PECULIARITIES OF IMMUNOLOGICAL RESPONCE DURING LIVER CIRRHOSIS DEPENDING ON SEVERITY LEVEL
- Authors: Paducheva S.V.1, Dolgikh O.V.2, Bulatova I.A.1, Shyokotova A.P.1
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Affiliations:
- Perm State Medical University named after E. A. Wagner" of the Ministry of Healthcare of Russia
- FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
- Issue: Vol 20, No 3 (2017)
- Pages: 463-465
- Section: Articles
- URL: https://ogarev-online.ru/1028-7221/article/view/119729
- ID: 119729
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Abstract
It has been established that the level of IL-6 in patients with subcompensated CP (class B) was significantly higher than in the compensated stage (p <0.001), and also had significant differences in patients with subcompensated and decompensated CP (p <0.001). The concentrations of VEGF and G-CSF significantly increased at the stage of severe cirrhosis (p <0.001 and p = 0.04, respectively). Proinflammatory cytokine TNF-α and anti-inflammatory IL-4 significantly increased during transition to the subcompensated stage of the disease (р=0.01 and р=0.04, respectively). There are no reliable differences between allelic variations of polymorphic gene loci TNF (G4682A), IL-6 (C174G) and VEGFA (G-634C), associated with liver cirrhosis severity levels, detected by us.
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About the authors
S. V. Paducheva
Perm State Medical University named after E. A. Wagner" of the Ministry of Healthcare of Russia
Author for correspondence.
Email: noemail@neicon.ru
Russian Federation
O. V. Dolgikh
FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Email: noemail@neicon.ru
Russian Federation
I. A. Bulatova
Perm State Medical University named after E. A. Wagner" of the Ministry of Healthcare of Russia
Email: noemail@neicon.ru
Russian Federation
A. P. Shyokotova
Perm State Medical University named after E. A. Wagner" of the Ministry of Healthcare of Russia
Email: noemail@neicon.ru
Russian Federation
References
- Булатова И. А. Взаимосвязь цитокинового статуса с тяжестью поражения печени и кишечника/ РОССИЙСКИЙ ИММУНОЛОГИЧЕСКИЙ ЖУРНАЛ, 2017, том 11 (20), №3 И. А. Булатова, А. П. Щекотова, Ю. И. Третьякова и др.// Новости «Вектор-Бест» -№ 2.-2014.-С. 8-13.
- Куликов В. Е., Тонеева М. А., Емелина Т. А. и др. // Международный научно-исследовательский журнал. 2015 № 4. doi: 10.18454/IRJ.2227-6017-
- Пузырев В. П., Фрейдлин М. Б. Роль генов интерлейкинов и их рецепторов в формировании предрасположенности к атопической бронхиальной астме//Бюлл.Эксп.Биол.Мед. -1999.Т.127. -Прил.1.- С. 3-6
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