USE OF STATINS FOR THE TREATMENT OF NON-INFECTIOUS UVEITIS
- Authors: Biryukova A.A.1, Shirinsky I.V.2
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Affiliations:
- S. N. Fyodorov Eye Microsurgery Complex, Novosibirsk Branch
- Federal State Budgetary Scientifi c Institution Research Institute of Fundamental and Clinical Immunology
- Issue: Vol 22, No 2-1 (2019)
- Pages: 165-167
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119453
- DOI: https://doi.org/10.31857/S102872210006437-5
- ID: 119453
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Abstract
Inhibitors of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase or statins, are used for the treatment of cardiovascular diseases and dyslipidemia. Immunomodulating and anti-infl ammatory properties of statins provide a rationale for their use in various autoimmune diseases including noninfectious uveitis. In this article we present literature data on the use of statins in the experimental models of non-infectious uveitis and on the epidemiological studies showing prophylactic eff ect of statins against uveitis. In our pilot, open-label, randomized study we demonstrated effi cacy and safety of treatment of uveitis with simvastatin in addition to conventional treatment. In conclusion, current data provide a rationale for a randomized, placebo controlled study of statins in uveitis.
About the authors
A. A. Biryukova
S. N. Fyodorov Eye Microsurgery Complex, Novosibirsk Branch
Author for correspondence.
Email: fake@neicon.ru
PhD student, ophthalmologist,
Novosibirsk
Russian FederationI. V. Shirinsky
Federal State Budgetary Scientifi c Institution Research Institute of Fundamental and Clinical Immunology
Email: ivan.shirinsky@gmail.com
leading research scientist, MD, PhD, Laboratory of Clinical Immunopharmacology,
Novosibirsk
Russian FederationReferences
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