ASSESSMENT OF THE FUNCTIONAL ACTIVITY OF ENDOTHELIUM IN WOMEN WITH HEAVY PREECLAMPSIA DEPENDING MANIFESTATIONS OF THE DISEASE
- Authors: Chistyakova G.N.1, Remizovа I.I.1, Aitov A.E.1
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Affiliations:
- Ural Scientific Research Institute of Maternity and Child Care
- Issue: Vol 22, No 2-1 (2019)
- Pages: 641-643
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120328
- DOI: https://doi.org/10.31857/S102872210006999-3
- ID: 120328
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Abstract
The functional activity of the endothelium and the level of pro- and anti-inflammatory mediators in women with severe pre-eclampsia (PE) were evaluated depending on the onset of the disease. It was established that the implementation of severe pre-eclampsia regardless of the timing of the manifestation (before or after 34 weeks of gestation) is accompanied by an increase in the level of endothelin-1, TNFα and C-reactive protein. In women with early PE, against the background of the revealed changes, an increase in the level of stable NO2 and IL-10 metabolites is noted, and from late PE, there is a homocysteine content, which makes it possible to use these indicators to assess the severity of preeclampsia with different periods
About the authors
G. N. Chistyakova
Ural Scientific Research Institute of Maternity and Child Care
Email: omm@niiomm.ru
MD, Professor, Head of the Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics,
Yekaterinburg
Russian FederationI. I. Remizovа
Ural Scientific Research Institute of Maternity and Child Care
Author for correspondence.
Email: RemizovaII@yandex.ru
Ph.D., Senior Researcher Department of Immunology, Microbiology, Pathomorphology and Cytodiagnostics,
Yekaterinburg
Russian FederationA. E. Aitov
Ural Scientific Research Institute of Maternity and Child Care
Email: fake@neicon.ru
correspondence postgraduate student,
Yekaterinburg
Russian FederationReferences
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