FEATURES OF CYTOKINES, ADIPOKINES, MATRIX MATELOPROTEINASE-9 AND ITS INHIBITORSIMBALANCE, DEPENDING ON THE CLINICAL MANIFESTATIONS OF ATHEROSCLEROSIS
- Authors: Turmova E.P.1, Markelova E.V.1, Kiku P.F.2
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Affiliations:
- Federal State Budget Educational Institution of Higher Education «Pacific state medical university» Health Ministry of Russian Federation
- Federal State Autonomous Educational Institution of Higher Education «Far Eastern Federal University» (FEFU)
- Issue: Vol 22, No 2-1 (2019)
- Pages: 584-586
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120309
- DOI: https://doi.org/10.31857/S102872210006982-5
- ID: 120309
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Abstract
140 patients with coronary atherosclerosis (CA), ischemic heart disease (IHD) and 120 people with obliterating atherosclerosis of lower extremities (OALE) were examined. The levels of IL-1β, IL-6, IFNγ, TNFα, IL-10, TGF-β1, TGF-β2, IL-2, IL-17, soluble cytokine receptors: IL-2R, IL- 6R, TNFα RI and TNFα RII, metalloproteinase-9 and its inhibitors (MMP-9, TIMP-1, MMP-9/TIMP-1, MMP-9/TIMP-2 complexes), adipokines (leptin and adiponectin) in serum. In patients with OALE, increase of IFNγ, TNFα, TN-α RII, IL-6 and TIMP-1 (p<0.05) was registered. By the factor analysis method, it was determined, that the IFNγ, IL-2, TNFα and IL-6 have leading pathogenetic significance in OALE. In patients with IHD, pathogenetic signifi cance and increase of the IL-1β, IL-17 and increase of the leptin was revealed.
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About the authors
E. P. Turmova
Federal State Budget Educational Institution of Higher Education «Pacific state medical university» Health Ministry of Russian Federation
Author for correspondence.
Email: eturmova@mail.ru
PhD, associate professor of the normal and pathological physiology department,
Vladivostok
Russian FederationE. V. Markelova
Federal State Budget Educational Institution of Higher Education «Pacific state medical university» Health Ministry of Russian Federation
Email: fake@neicon.ru
PhD, professor, head of the normal and pathological physiology department,
Vladivostok
Russian FederationP. F. Kiku
Federal State Autonomous Educational Institution of Higher Education «Far Eastern Federal University» (FEFU)
Email: fake@neicon.ru
Ph.D., professor of Biomedicine school (Preventive medicine department),
Vladivostok
Russian FederationReferences
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