CONTENT OF GALECTINS-2, -9 AND SUBPOPULATIONS OF BLOOD MONOCYTES IN PATHOLOGY OF LUNG INFECTIOUS AND NON-INFECTIOUS GENESIS
- Authors: Chumakovа S.P.1, Vins M.V.1, Urazovа O.I.1, Bukreeva E.B.1, Bulanova A.A.1, Churinа E.G.1, Sitnikovа A.V.1, Novitsky V.V.1
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Affiliations:
- Siberian State Medical University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 966-968
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/120066
- DOI: https://doi.org/10.31857/S102872210006502-7
- ID: 120066
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Abstract
15 patients with infiltrative pulmonary tuberculosis (TB), 16 patients with chronic obstructive pulmonary disease (COPD) and 12 healthy donors were examined. Amount of CD14hiCD16–, CD14hiCD16lo, CD14loCD16lo and CD14loCD16– monocytes in the blood was evaluated by flow-cytometry, and galectin-2 and -9 concentration was measured by ELISA. Increase in the number of CD14hiCD16lo monocytes, differentiated from the CD14hiCD16– cells, and decrease in the content of galectin-2 and CD14lo CD16– monocytes in the blood were characteristic of TB. In COPD, an increase in the concentration of galectin-9 and the proportion of CD14hiCD16– monocytes against the background of deficiency of other their subpopulations in the blood was noted.
About the authors
S. P. Chumakovа
Siberian State Medical University
Author for correspondence.
Email: fake@neicon.ru
Doctor of Medical Sciences, Professor at the Department of Pathophysiology,
Tomsk
Russian FederationM. V. Vins
Siberian State Medical University
Email: wmw_1991@mail.ru
Assistant at the Department of Pathophysiology,
Tomsk
Russian FederationO. I. Urazovа
Siberian State Medical University
Email: fake@neicon.ru
Doctor of Medical Sciences, Professor, Corresponding Member of the RAS, Head of the Department of Pathophysiology,
Tomsk
Russian FederationE. B. Bukreeva
Siberian State Medical University
Email: fake@neicon.ru
Doctor of Medical Sciences, Professor of the Department of Internal Medicine Propaedeutics with the course of therapy of the Pediatric faculty,
Tomsk
Russian FederationA. A. Bulanova
Siberian State Medical University
Email: fake@neicon.ru
PhD of Medical Sciences, Assistant of the Department of Internal Medicine Propaedeutics with the course of therapy of the Pediatric Faculty,
Tomsk
Russian FederationE. G. Churinа
Siberian State Medical University
Email: fake@neicon.ru
Doctor of Medical Sciences, Professor at the Department of Pathophysiology,
Tomsk
Russian FederationA. V. Sitnikovа
Siberian State Medical University
Email: fake@neicon.ru
Postgraduate at the Department of Pathophysiology,
Tomsk
Russian FederationV. V. Novitsky
Siberian State Medical University
Email: fake@neicon.ru
Doctor of Medical Sciences, Professor, Academician of the RAS, Honored Scientist of the Russian Federation, Professor of the Department of Pathophysiology,
Tomsk
Russian FederationReferences
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