THE REGULATION OF TREG DIFFERENTIATION BY ENDOGENOUS MELATONIN DURING PREGNANCY
- Authors: Glebezdina N.S.1, Olina A.A.2, Nekrasova I.V.1, Kuklina E.M.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, UB RAS
- Perm State Medical University named after academician E. A. Wagner of the Ministry of healthcare of the Russian Federation
- Issue: Vol 20, No 2 (2017)
- Pages: 285-286
- Section: Articles
- URL: https://ogarev-online.ru/1028-7221/article/view/119895
- ID: 119895
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Abstract
The role of endogenous melatonin in the regulation of the process of regulatory T cells (Treg) differentiation during the gestation period has been studied. The difference in the regulation of this process by the hormone was shown in non-pregnant and pregnant women. The positive effect of melatonin on the cells in vitro mediated by signals from membrane receptors for the hormone in response to polyclonal activation was revealed at pregnancy.
Keywords
About the authors
N. S. Glebezdina
Institute of Ecology and Genetics of Microorganisms, UB RAS
Author for correspondence.
Russian Federation
A. A. Olina
Perm State Medical University named after academician E. A. Wagner of the Ministry of healthcare of the Russian FederationRussian Federation
I. V. Nekrasova
Institute of Ecology and Genetics of Microorganisms, UB RASRussian Federation
E. M. Kuklina
Institute of Ecology and Genetics of Microorganisms, UB RASRussian Federation
References
- Wu L., Luo L.- H., Zhang Y.- X., Li Q., Xu B. et al. Alteration of Th 17 and Treg cells in patients with unexplained recurrent spontaneous abortion before and after lymphocyte immunization therapy. Re-prod. Biol. Endocrinol. 2014, 12, 74.
- Steinborn A., Schmitt E., Kisielewicz A., Rechenberg S., Seissler N. et al. Pregnancy-associated diseases are characterized by the composition of the systemic regulatory T cell (Treg) pool with distinct subsets of Tregs. Clin. Exp. Immunol. 2012, 167(1), 84-98.
- Lardone P. J., Guerrero J. M., Fernandez-Santos J. M., Rubio A., Martin-Lacave I. et al. Melatonin synthesized by T lymphocytes as a ligand of the retinoic acid-related orphan receptor. J. Pineal. Res. 2011, 51(4), 454-462.
- Farez M. F., Mascanfroni I. D., Mendez-Huergo S. P., Yeste A., Murugaiyan G. et al. Melatonin contributes to the seasonality of multiple sclerosis relapses. Cell. 2015, 162 (6), 1338-1352.
- Ziegler S. F., Buckner J. H. FOXP3 and the regulation of Treg/Th17 differentiation. Microbes Infect. 2009, 11(5), 594-598.
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