COMPLEX CORRECTION OF IMMUNE VIOLATIONS IN INTERNAL ENDOMETRIOSIS
- Authors: Ivanova O.Y.1, Telegina O.V.2, Ponomareva N.A.1, Elagina K.A.1, Kolomoets I.I.1
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Affiliations:
- Kursk State Medical University, Ministry of Health of the Russian Federation
- State Healthcare Institution Lipetsk regional perinatal center
- Issue: Vol 22, No 2-1 (2019)
- Pages: 284-286
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119778
- DOI: https://doi.org/10.31857/S102872210006602-7
- ID: 119778
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Abstract
42 patients with a verifi ed diagnosis of adenomyosis stage II‒III were under constant observation. The concentration of pro-, anti-infl ammatory and regulatory cytokines, components of the complement and their inhibitors was determined in the blood plasma and aspirate from the uterine cavity. Prior to treatment, an increase in systemic and local concentrations of pro-infl ammatory (TNFα, IL-1β, IL-6, IL-8, IL-17, IL-18), IFNγ, G-CSF, IL-2, anti-infl ammatory (IL-4, IL-1RA) cytokines, an increase in the level of the complement components (C3, C3a, C4, C5, C5a) with an imbalance in the content of their regulators (an increase in factor H and a decrease in the C1 inhibitor). The combination of standard treatment in combination with Ridostin, Hypoxen and Essentiale forte H eff ectively corrected altered immune status parameters.
About the authors
O. Yu. Ivanova
Kursk State Medical University, Ministry of Health of the Russian Federation
Author for correspondence.
Email: ivanovao1@mail.ru
MD, Associate Professor, Head of the Department of Obstetrics and Gynecology,
Kursk
Russian FederationO. V. Telegina
State Healthcare Institution Lipetsk regional perinatal center
Email: fake@neicon.ru
deputy chief physician for outpatient care,
Lipetsk
Russian FederationN. A. Ponomareva
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: fake@neicon.ru
MD, Associate Professor, Professor of the Department of Obstetrics and Gynecology,
Kursk
Russian FederationK. A. Elagina
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: fake@neicon.ru
6th year student of the medical faculty,
Kursk
Russian FederationI. I. Kolomoets
Kursk State Medical University, Ministry of Health of the Russian Federation
Email: fake@neicon.ru
Assistant, Department of Biochemistry,
Kursk
Russian FederationReferences
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