THE STATE OF CONNECTIVE TISSUE ELEMENTS OF THE LIVER WITH DIFFUSE TOXIC DAMAGE AND ITS CORRECTION
- Authors: Medvedeva S.Y.1,2, Shafigullina Z.A.1,2, Danilova I.G.1,2
-
Affiliations:
- Institute of Natural Sciences and Mathematics of the Ural Federal University named after the first President of Russia Boris Yeltsin
- Institute of Immunology and Physiology, Ural Branch of RAS
- Issue: Vol 22, No 2-2 (2019)
- Pages: 861-863
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119775
- DOI: https://doi.org/10.31857/S102872210006647-6
- ID: 119775
Cite item
Full Text
Abstract
An experimental model of diffuse toxic rat liver damage with carbon tetrachloride (CCl4) and its correction by aminophthalhydrazide (APH) was used to evaluate the response of mast cells and the degree of fibrosis. Structural disorders and suppression of regenerative processes in the liver under conditions of chemical trauma were accompanied by increased migration of mast cells to the portal stroma and an increased content of secretory granules in them. The use of APH contributes to the normalization of the area, occupied by collagen in the liver tissue, and reduces the number of mast cells, but maintains a high content of secretory granules in them.
Keywords
About the authors
S. Yu. Medvedeva
Institute of Natural Sciences and Mathematics of the Ural Federal University named after the first President of Russia Boris Yeltsin;Institute of Immunology and Physiology, Ural Branch of RAS
Author for correspondence.
Email: fake@neicon.ru
Ph.D. of Medical Sciences;
associate professor leading researcher,
Ekaterinburg
Russian FederationZ. A. Shafigullina
Institute of Natural Sciences and Mathematics of the Ural Federal University named after the first President of Russia Boris Yeltsin;Institute of Immunology and Physiology, Ural Branch of RAS
Email: zlata_pyankova@mail.ru
post-graduate student;
junior researcher,
Ekaterinburg
Russian FederationI. G. Danilova
Institute of Natural Sciences and Mathematics of the Ural Federal University named after the first President of Russia Boris Yeltsin;Institute of Immunology and Physiology, Ural Branch of RAS
Email: fake@neicon.ru
doctor of biological sciences, associate professor;
head of the Laboratory of Morphology and Biochemistry,
Ekaterinburg
Russian FederationReferences
- Юшков Б. Г., Черешнев В. А., Климин В. Г., Арташян О. С. Тучные клетки: физиология и патофизиология. Медицина, M 2011, 240.
- Vogel B., Siebert H., Hofmann U., Frantz S. Determination of collagen content within picrosirius red stained paraffi n-embedded tissue sections using fluorescence microscopy. MethodsX. 2015, 2, 124–134.
- Francis H., Cynthia J., Meininger A. Review of mast cells and liver disease: What have we learned? Digestive and Liver Disease. 2010, 42, 529–536.
Supplementary files
