IMMUNOPATOGENIC FEATURES OF HEMORRHAGIC FEVER WITH RENAL SYNDROME IN THE DYNAMICS OF THE INFECTIOUS PROCESS
- 作者: Ivanov M.F.1, Zhestkov A.V.1, Suzdalcev A.A.1, Popova L.L.1, Balmasova I.P.2,3
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隶属关系:
- Samara State Medical University
- A.I.Evdokimov Moscow Univercity of Medcine & Dentistry
- Peoples ‘ Friendship University of Russia
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 281-283
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119771
- DOI: https://doi.org/10.31857/S102872210006601-6
- ID: 119771
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详细
Hemorrhagic fever with renal syndrome (HFRS) is an acute zoonotic viral infection, clinically manifested by a hemorrhagic syndrome and acute renal failure. The aim of the work was to study the dynamics of lymphocytes of innate and adaptive immune response in patients with HFRS during feverish, oliguric, polyuric periods and in reconvalescence. There were some features of the immunopathogenesis of HFRS: a high content in blood of regulatory T-lymphocytes, the prevalence in the initial stages of the disease reaction of natural killer cells, the delay of the development of adaptive cellular immune response involving cytotoxic T-lymphocytes.
作者简介
M. Ivanov
Samara State Medical University
编辑信件的主要联系方式.
Email: fake@neicon.ru
PhD, associate professor of the Department of General and Clinical Microbiology, Immunology and Allergology,
Moscow
俄罗斯联邦A. Zhestkov
Samara State Medical University
Email: fake@neicon.ru
MD, professor, Head of the Department of General and Clinical Microbiology, Immunology and Allergology,
Moscow
俄罗斯联邦A. Suzdalcev
Samara State Medical University
Email: fake@neicon.ru
MD, Professor, Head of the Department of Infectious Diseases and Epidemiology,
Moscow
俄罗斯联邦L. Popova
Samara State Medical University
Email: fake@neicon.ru
MD, Professor of the Department of infectious diseases and Epidemiology,
Moscow
俄罗斯联邦I. Balmasova
A.I.Evdokimov Moscow Univercity of Medcine & Dentistry;Peoples ‘ Friendship University of Russia
Email: iri.balm@mail.ru
MD, Professor, Head of the Laboratory of the Pathogenesis and Treatment of Infectious Diseases;
Professor of Allergology and Immunology Department of Medical Institute,
Moscow
俄罗斯联邦参考
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- Сиротин Б. З. Вопросы классификации геморрагической лихорадки с почечным синдромом. Клиническая медицина. 1977, 55(2): 117–123.
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- Zheng X, Ye C, Zhao J, Bian P, Zhang Y, Jia Z. Alterations and clinical signifecance of exosome-containing innate immunity related lncRNAs in patients of hemorrhagic fever with renal syndrome. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016, 32(11):1522–1526.
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