EFFECT OF PREGNANCY-SPECIFIC β1-GLYCOPROTEIN ON CHEMOKINE PROFILE OF CULTURED T-HELPER AND MONONUCLEAR CELLS
- Authors: Zamorina S.A.1, Litvinova L.S.2, Yurova K.A.2, Khaziakhmatova O.G.2, Timganova V.P.1, Bochkova M.S.1, Khramtsov P.V.1,2, Rayev M.B.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms UB RAS
- Immanuel Kant Baltic Federal University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 257-259
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119695
- DOI: https://doi.org/10.31857/S102872210006593-7
- ID: 119695
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Abstract
The effect of human pregnancy-specific β1-glycoprotein (PSG) on the production of chemokines by intact mononuclear cells and monocultures of CD4+ cells in vitro by Bio-Plex® multiplex immunoassay technology was studied. It has been established that PSG suppresses the production of IL-8, MIP-1α, MIP-1β, RANTES and MCP-1, chemokines, an elevated level of which is associated with spontaneous abortion. As a result, it can be concluded that PSG forms the fetoprotective chemokine profile of the studied immune cells.
About the authors
S. A. Zamorina
Institute of Ecology and Genetics of Microorganisms UB RAS
Author for correspondence.
Email: mantissa7@mail.ru
PhD, MD (Biology), leading researcher,
Perm
Russian FederationL. S. Litvinova
Immanuel Kant Baltic Federal University
PhD, MD (Medicine), Head, Basic Laboratory of Immunology and Cell Biotechnologies,
Kaliningrad
Russian FederationK. A. Yurova
Immanuel Kant Baltic Federal University
PhD (Medicine), Researcher,
Kaliningrad
Russian FederationO. G. Khaziakhmatova
Immanuel Kant Baltic Federal UniversityKaliningrad Russian Federation
V. P. Timganova
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, junior researcher,
Perm
Russian FederationM. S. Bochkova
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, researcher,
Perm
Russian FederationP. V. Khramtsov
Institute of Ecology and Genetics of Microorganisms UB RAS;Immanuel Kant Baltic Federal University
PhD, researcher, Perm;
researcher, Kaliningrad
Russian FederationM. B. Rayev
Institute of Ecology and Genetics of Microorganisms UB RAS
PhD, MD, Leading Researcher,
Perm
Russian FederationReferences
- Du M.-R., Wang S. C., Li D. J. The integrative roles of chemokines at the maternal-fetal interface in early pregnancy // Cell. Mol. Immunol. 2014; 11(5): P. 438– 448.
- Раев М. Б. Способ выделения и очистки трофобластического β-1-гликопротеина. Патент РФ № 2367449 от 20.09.2009. / «Изобретения. Полезные модели». – 2009. – № 26.
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