STUDY OF THE CONTENT OF IgG AND IgM LEVEL IN EXPERIMENTAL ULCER AND IN THE CONDITIONS OF RECTAL SUPPOSITORIES WITH VITAMIN D3

Basic therapy of ulcerative colitis (UC) includes 5-aminosalicylic acid derivatives (5-ASA), glucocorticoids, and other drugs that have side effects that limit their use, therefore, the search for and justification of the use of new drugs for pharmacotherapy is necessary. The aim of the work is to study the effects of rectal suppositories with vitamin D3 on serum IgG and IgM concentrations in experimental UC. Work performed on 70 Wistar rats. UC was modeled in two stages: 1 – skin sensitization of an animal with a 3% oxazolone solution, 2 – rectal administration of 3% oxazolone. An aqueous solution of vitamin D3 in the composition of rectal suppositories of the original composition based on polyethylene glycol was used every 12 hours; in the comparison group, rectal suppositories with 5-ASA were used in the same way. The serum concentration of IgG and IgM was determined by ELISA using specific test systems on days 2, 4 and 6 of the experiment. The work revealed a statistically significant decrease in the concentration of immunoglobulins in terms of the use of rectal suppositories with vitamin D3 on days 4 and 6 of experimental ulcerative colitis.

ulcerative colitis, vitamin D3, IgG, IgM, rectal suppositories