MICROBICIDAL EFFECT OF SECRETORY PRODUCTS OF NEUTROPHILS IN RELATION TO REPRESENTATIVES OF RESIDENT AND CONDITIONALY PATHOGENIC MICROFLORA OF A HUMAN BODY

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Abstract

A study of 50 samples of intact and activated neutrophil supernatants from S. aureus (strain 209), E. сoli (strain M-17), Lactobacterium spp., Bifi dobacterium spp. has been conducted. It has been determined that in vitro induction of neutrophils by representatives of the resident and conditionally pathogenic microflora of the human body leads to secretion of biologically active products of different composition. Thus, the interaction of neutrophils with Lactobacterium spp. and, to a greater extent, Bifidobacterium spp. significantly increases the level of nitric oxide in supernatants, while the content of peroxidase and catalase does not change. This is accompanied by a significant increase in the microbicide of neutrophil secretion products in relation to S. aureus and E. coli, without affecting the viability of Lactobacterium spp. and Bifidobacterium spp.

About the authors

E. V. Kolbina

Federal State Budgetary Educational Institution of Higher Education «South-Ural State Medical University» of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: kaplech@mail.ru

PhD M.S., Senior Teacher of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

Yu. S. Shishkova

Federal State Budgetary Educational Institution of Higher Education «South-Ural State Medical University» of the Ministry of Healthcare of the Russian Federation

MD M.S., Professor of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

E. A. Mezentseva

Federal State Budgetary Educational Institution of Higher Education «South-Ural State Medical University» of the Ministry of Healthcare of the Russian Federation

PhD M.S., Docent of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

I. A. Kolbin

Federal State Budgetary Educational Institution of Higher Education «South-Ural State Medical University» of the Ministry of Healthcare of the Russian Federation

Assistant of the Department of Microbiology, Virology, Immunology and Clinical Laboratory Diagnostics,

Chelyabinsk

Russian Federation

References

  1. Долгушин И. И., Андреева Ю. С., Мезенцева Е. А., Савочкина А. Ю., Плеханова Е. В., Свиридов М. А., Пешикова М. В. Нейтрофилы регулируют формирование микробиоценоза слизистых оболочек. Медицинская иммунология. 2006, 8; 2–3, 135– 136.
  2. Долгушин И. И., Андреева Ю. С., Савочкина А. Ю. Нейтрофильные внеклеточные ловушки и методы оценки функционального статуса нейтрофилов. Издательство РАМН, Москва 2009, 208.
  3. Плеханова Е. В. Влияние факторов цервикального секрета (факультативной и резидентной флоры, муцина) на функциональные свойства нейтрофилов: дис. … канд. мед. наук. Челябинск, 2007.

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Copyright (c) 2019 Kolbina E.V., Shishkova Y.S., Mezentseva E.A., Kolbin I.A.

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