PROPERTIES OF HUMAN NATURAL KILLER CELL SUBPOPULATIONS EXPRESSING MARKERS OF ADAPTIVE CELLS
- Authors: Kobyzeva P.A.1, Streltsova M.A.1, Erokhina S.A.1, Kovalenko E.I.1
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Affiliations:
- Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Issue: Vol 22, No 2-2 (2019)
- Pages: 795-797
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119606
- DOI: https://doi.org/10.31857/S102872210006695-9
- ID: 119606
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Abstract
Natural killer cells are attributed to lymphocytes of innate immunity for their ability of spontaneous antitumor activity without prior activation. However, recent studies have shown that some viral infections, such as human cytomegalovirus, can cause an increase in the number of NK cells with the phenotype CD57+NKG2C+ compared to healthy donors. It is assumed that cells of this subpopulation have some properties of adaptivity and immunological memory to HCMV infection. This paper is devoted to the study of properties of human NK-cell subpopulations selected for the markers CD57 and NKG2C, when stimulated with IL-2 and membrane-bound IL-21.
About the authors
P. A. Kobyzeva
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Author for correspondence.
bachelor, Laboratory of Cell Interactions,
Moscow
Russian FederationM. A. Streltsova
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Junior Researcher of Laboratory of Cell Interactions,
Moscow
Russian FederationS. A. Erokhina
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
PhD Student, Laboratory of Cell Interactions,
Moscow
Russian FederationE. I. Kovalenko
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: lenkovalen@mail.ru
PhD, Senior Researcher of Laboratory of Cell Interactions,
Moscow
Russian FederationReferences
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- Kovalenko E. I., Streltsova M. A., Kanevskiy L. M., Erokhina S. A., Telford W. G. Identification of Human Memory-Like NK Cells. Curr Protoc Cytom. 2017, 79, 9.50.1–9.50.11.
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