THE ROLE OF PREGNANCY-SPECITIC GLYCOPROTEIN IN THE REGULATION OF PRODUCTION OF KEY CYTOKINES THAT DETERMINE BALANCE Th1 / Th2

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Abstract

The effect of pregnancy-specific glycoprotein (PSG) on the production of Th1/Th2-cytokines by intact mononuclear cells and monocultures of CD4 cells under in vitro conditions by flow-through fluorimetry was studied. It has been established that PSG predominantly suppresses the production of Th1-cytokines (IFN-γ, TNF-α, IL-2) by the types of cells studied, and it regulates the production of Th2-cytokines in different directions, decreasing the production of IL-9, IL-13, IL-6, but increasing the level of IL-5. As a result, PSG forms the integral Th2-cytokine profile of intact peripheral cells of the immune system.

About the authors

S. A. Zamorina

Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University

Author for correspondence.
Russian Federation

L. S. Litvinova

Immanuel Kant Baltic Federal University

Russian Federation

K. A. Yurova

Immanuel Kant Baltic Federal University

Russian Federation

O. G. Khaziakhmatova

Immanuel Kant Baltic Federal University

Russian Federation

V. P. Timganova

Institute of Ecology and Genetics of Microorganisms UB RAS

Russian Federation

M. S. Bochkova

Institute of Ecology and Genetics of Microorganisms UB RAS

Russian Federation

P. V. Khramtsov

Perm State National Research University

Russian Federation

M. B. Rayev

Institute of Ecology and Genetics of Microorganisms UB RAS; Perm State National Research University

Russian Federation

References

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  3. Раев М. Б. Cпособ выделения и очистки трофобластического β-1-гликопротеина. Патент РФ № 2367449 от 20.09.2009. / Раев М. Б.// «Изобретения. Полезные модели». 2009. № 26.

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Copyright (c) 2017 Zamorina S.A., Litvinova L.S., Yurova K.A., Khaziakhmatova O.G., Timganova V.P., Bochkova M.S., Khramtsov P.V., Rayev M.B.

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