RELATIONSHIP CHARACTER OF COLLAGEN SYNTHESIS IN UTERINE LEIOMYOMA TISSUE WITH FEATURES OF TUMOR GROWTH
- Authors: Voskresenskaya D.L.1, Malyshkina A.I.2, Antsiferova Y.S.2
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Affiliations:
- FSBE «Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov» of Healthy Ministry of Russian Federation Ivanovo
- FSBE «Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov» of Healthy Ministry of Russian Federation
- Issue: Vol 22, No 2-1 (2019)
- Pages: 192-193
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119518
- DOI: https://doi.org/10.31857/S102872210006452-2
- ID: 119518
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Abstract
The aim of the work was to elucidate the features of collagen 1A1 mRNA expression in uterine leiomyoma. It was found that the high level of collagen synthesis is associated with rapidly increase of leiomyoma size, more frequently noted in small tumors with minimal proliferative activity. Thus, the activity of tissue fi broblasts defi nes the features of tempo and character growth of uterine leiomyoma.
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About the authors
D. L. Voskresenskaya
FSBE «Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov» of Healthy Ministry of Russian Federation Ivanovo
Author for correspondence.
Email: kasyanikdariakis@mail.ru
graduate student of the laboratory of Clinical immunology,
Ivanovo
Russian FederationA. I. Malyshkina
FSBE «Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov» of Healthy Ministry of Russian Federation
MD, professor, director,
Ivanovo
Russian FederationYu. S. Antsiferova
FSBE «Ivanovo’s Research Institute of Maternity and Childhood named after V. N. Gorodkov» of Healthy Ministry of Russian Federation
BD, the leading scientifi c worker of the laboratory of Clinical immunology,
Ivanovo
Russian FederationReferences
- Миома матки / под ред. И. С. Сидоровой. – М.: МИА, 2003. – 256 с./ Uterine leiomyoma. Ed I. S. Sidorova. – M.: MIA, 2003. – 256 p.
- Иммунные механизмы быстрого роста миомы матки / А. И. Малышкина, Н. Ю. Сотникова, Ю. С. Анциферова, А. К. Красильникова. – Иваново, 2010. –272 с.
- Chegini N. Proinflammatory and profibrotic mediators: Principal effectors of leiomyoma development as a fibrotic disorder // Semin Reprod Med. – 2010. – № 28(3). – P. 180–203.
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