THE ROLE OF CD4+CD25+CD127– T CELLS AND CYTOKINE RESPONSE IN THE REGULATION OF SYSTEMIC INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE
- Authors: Vitkina T.I.1, Lysak A.A.1,2, Sidletskaya K.A.1
-
Affiliations:
- Vladivostok Branch of Federal State Budgetary Science Institution “Far Eastern Scientifi c Center of Physiology and Pathology of Respiration” – Institute of Medical Climatology and Rehabilitative Treatment
- Far Eastern Federal University
- Issue: Vol 22, No 2-1 (2019)
- Pages: 187-189
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119503
- DOI: https://doi.org/10.31857/S102872210006449-8
- ID: 119503
Cite item
Full Text
Abstract
The regulatory mechanisms of systemic infl ammation in chronic obstructive pulmonary disease (COPD) are not well understood. The aim is to establish the features of immunosuppressive reactions in COPD patients. The study included 112 patients with stable mild-to-severe COPD and 32 healthy volunteers. Cytokine levels (IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, IFN-γ) and T-regulatory cell (Treg) number were determined using fl ow cytometry. A decrease in Treg number has been foundinsevere COPD. The mechanism of this process may be their competitive interaction with T helper (Th) 17 cells, which is mediated by IL-6action. Ultimately, it contributes to Th17/Treg disbalance and the switching of Th1 immune response to Th17, leading to worsening COPD.
About the authors
T. I. Vitkina
Vladivostok Branch of Federal State Budgetary Science Institution “Far Eastern Scientifi c Center of Physiology and Pathology of Respiration” – Institute of Medical Climatology and Rehabilitative Treatment
Email: fake@neicon.ru
д. б. н., проф., ведущий научный сотрудник лаборатории биомедицинских исследований,
Владивосток
Russian FederationA. A. Lysak
Vladivostok Branch of Federal State Budgetary Science Institution “Far Eastern Scientifi c Center of Physiology and Pathology of Respiration” – Institute of Medical Climatology and Rehabilitative Treatment;Far Eastern Federal University
Author for correspondence.
Email: francium.ru@mail.ru
лаборант-исследователь лаборатории медицинской экологии и рекреационных ресурсов, 690105, Владивосток, ул. Русская, д. 73-г;
студент биологического факультета, Владивосток
Russian FederationK. A. Sidletskaya
Vladivostok Branch of Federal State Budgetary Science Institution “Far Eastern Scientifi c Center of Physiology and Pathology of Respiration” – Institute of Medical Climatology and Rehabilitative Treatment
Email: fake@neicon.ru
младший научный сотрудник лаборатории биомедицинских исследований,
Владивосток
Russian FederationReferences
- Chiappori A., Folli Ch., Balbi F., Caci E., Riccio A., Ferrari De L., Melioli G., Braido F., Walter G. CD4+ CD25highCD127– regulatory T-cells in COPD: smoke and drugs eff ect. World Allergy Organ J. 2016; 9:5.
- Ito J. T., Cervilha D. A. de B., Lourenço J. D., Gonçalves N. G., Volpini R. A., Caldini E. G., Landman G., Lin Ch. J., Teodoro W. P. R., Tibério I. de F. L. C., Martins M. de A., Lopes F. D. T. Qu. dos S. Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model. PLoSOne. 2019; 14(1), 1–19.
- Калинина Е. П., Виткина Т. И., Кнышова В. В., Федосеева Е. А., Новгородцева Т. П., Гвозденко Т. А. Кли нико-иммунологическое сопоставление при Th-за висимых механизмах иммунного ответа у больных хронической обструктивной болезнью легких. Медицинская иммунология. 2018;20(6): 855–864.
Supplementary files
