MECHANISMS OF FORMATION OF BRONCHIAL OBSTRUCTION IN CHILDREN OF PRESСHOOL AGE
- Authors: Gaymolenko I.N.1, Potapova N.L.1, Petrova A.I.1
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Affiliations:
- Chita State Medical Academy
- Issue: Vol 22, No 4 (2019)
- Pages: 1447-1449
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119497
- DOI: https://doi.org/10.31857/S102872210007053-3
- ID: 119497
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Abstract
Investigated the indices of some cytokines and chemokines in peripheral blood serum (IL-1β, IL-6, IL-8, IL-10, IFN-α, IFN-β, IFN-γ, TFN-α, MCP-1, RANTES, MIP-1α, MIP-1β) in children with acute bronchitis. When evaluating concentrations of cytokines in peripheral blood serum of the patients with acute bronchitis in general (n = 87 people) we revealed significantly higher levels of IL-8, IFN-β, MCP-1, RANTES, MIP-1α, MIP-1β, as compared to control group. It was established that MIP-1α и MIP-1β concentration in the group of children with acute simple bronchitis is twice as high as in children with acute obstructive bronchitis. Immunological markers of acute obstructive bronchitis are lower serum concentrations of MIP-1α and MIP-1β, with high IL-10 values, which confirms the significance of the Th2 pathway in the pathogenesis of bronchial obstruction.
Keywords
About the authors
I. N. Gaymolenko
Chita State Medical Academy
Author for correspondence.
Email: ingaim@mail.ru
Dr. Sc., professor, Head of the Department of Pediatrics,
Chita
Russian FederationN. L. Potapova
Chita State Medical Academy
Email: fake@neicon.ru
postgraduate student of the Department of Pediatrics,
Chita
Russian FederationA. I. Petrova
Chita State Medical Academy
Email: fake@neicon.ru
PhD, Head of the Department of Outpatient Pediatrics with a course of medical rehabilitation,
Chita
Russian FederationReferences
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