FACTORS OF IMMUNOENDOCRINE REGULATION IN ALCOHOL DEPENDENCE AT THE STAGE OF FORMATION OF THERAPEUTIC REMISSION
- 作者: Vetlugina T.P.1, Nikitina V.B.1, Mandel A.I.1, Boiko A.S.1, Prokopieva V.D.1, Bokhan N.A.1
-
隶属关系:
- Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
- 期: 卷 22, 编号 2-1 (2019)
- 页面: 183-186
- 栏目: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119496
- DOI: https://doi.org/10.31857/S102872210006447-6
- ID: 119496
如何引用文章
全文:
详细
The aim of the study was to study the dynamics of the immunoendocrine factors in patients with alcohol dependence in the process of therapy of withdrawal syndrome and post-withdrawal state. In 35 men with alcohol dependence in the dynamics of formation of therapeutic remission, the level of spontaneous production of spectrum of cytokines by immunocompetent cells was investigated; in the blood serum – hormones. Control – 19 practically healthy men. Hyperproduction of proinfl ammatory cytokines, increase in the concentration of cortisol, decrease in the concentration of T3 and T4 were established. Dependence of IFNγ, IL-1ra, IL-2 and testosterone on character of remission was revealed that allows considering these factors as candidates into biomarkers of prediction of the stability of remission.
作者简介
T. Vetlugina
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: vetlug@mail.tomsknet.ru
D. Sc., Prof., lead researcher of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology, Head of the Department of Biological Psychiatry and Narcology,
Tomsk
俄罗斯联邦V. Nikitina
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
MD, Head of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology,
Tomsk
俄罗斯联邦A. Mandel
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
MD, Prof., lead researcher of Addictive States Department,
Tomsk
俄罗斯联邦A. Boiko
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
PhD, researcher of the Laboratory of Molecular Genetics and Biochemistry,
Tomsk
俄罗斯联邦V. Prokopieva
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
D. Sc., lead researcher of Laboratory of Clinical Psychoneuroimmunology and Neurobiology, Head of the Department of Biological Psychiatry and Narcology,
Tomsk
俄罗斯联邦N. Bokhan
Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: fake@neicon.ru
MD, Prof., academician of RAS, Head of Addictive States Department, Director,
Tomsk
俄罗斯联邦参考
- Vetreno R. P., Crews F. T. Current hypotheses on the mechanisms of alcoholism. Handb Clin Neurol. 2014, 125, 477–497. doi: 10.1016/B978-0-444-62619-6.00027-6
- Мандель А. И., Артемьев И. А., Ветлугина Т. П., Иванова С. А., Невидимова Т. И., Прокопьева В. Д., Аболонин А. Ф., Шушпанова Т. В. Биологические предикторы, клинико-патогенетические механизмы формирования и профилактика аддиктивных состояний в различных социальных группах (итоги комплексной темы НИР ФГБУ «НИИПЗ» СО РАМН, 2009–2012 гг.) Сибирский вестник психиатрии и наркологии. 2013, 4(79), 40–48.
- Crews F. T., Lawrimore C. J., Walter T. J., Coleman L. G. Jr. The role of neuroimmune signaling in alcoholism. Neuropharmacology. 2017, 1, 122, 56–73. doi: 10.1016/j.neuropharm.2017.01.031
- Blaine S. K., Sinha R. Alcohol, stress, and glucocorticoids: From risk to dependence and relapse in alcohol use disorders. Neuropharmacology. 2017, 122, 136– 147. doi: 10.1016/j.neuropharm.2017.01.037.
- Lenz B., Müller C. P., Stoessel C., Sperling W., Biermann T., Hillemacher T., Bleich S., Kornhuber J. Sex hormone activity in alcohol addiction: integrating organizational and activational eff ects. Prog Neurobiol. 2012, 96(1), 136–63. doi: 10.1016/j.pneurobio.2011.11.001.
补充文件
