LABORATORY POSSIBILITY IN THE DIAGNOSIS OF DRUG HYPERSENSITIVITY
- Authors: Bychkova N.V.1,2
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Affiliations:
- NRCERM EMERCOM of Russia
- Saint-Petersburg State Medical University named after I. P. Pavlov
- Issue: Vol 22, No 2-1 (2019)
- Pages: 180-182
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119490
- DOI: https://doi.org/10.31857/S102872210006446-5
- ID: 119490
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Abstract
Drug hypersensitivity reactions are not very common in the population, but can be a serious problem for patients and physicians. Diagnosis of this disorder should consist of a complex of clinical and laboratory methods. A promising method of in vitro diagnostics is the basophil activation test. The study showed the high diagnostic significance of this test in determining hypersensitivity to radiocontrast media and local anesthetics. The presence of in vitro hypersensitivity to drugs can be latent in nature and manifest itself clinically only if the regulatory capabilities are impaired.
About the authors
N. V. Bychkova
NRCERM EMERCOM of Russia;Saint-Petersburg State Medical University named after I. P. Pavlov
Author for correspondence.
Email: BNV19692007@yandex.ru
PhD, Senior Researcher of the Laboratory of Clinical Immunology of the Department of Laboratory Diagnostics;
Assistant-Professor of the Department of Immunology,
Saint-Petersburg
Russian FederationReferences
- Sousa-Pinto B., Fonseca J. A., Gomes E. R. Frequency of self-reported drug allergy: A systematic review and meta-analysis with meta-regression. Ann Allergy Asthma Immunol. 2017, 119(4), 362–373.
- Kim M. H., Park C. H., Kim D. I., Kim K. M., Kim H. K., Lim K. H., Song W. J., Lee S. M., Kim S. H., Kwon H. S., Park H. W., Yoon C. J., Cho S. H., Min K. U., Kim Y. Y., Chang Y. S. Surveillance of contrast-media-induced hypersensitivity reactions using signals from an electronic medical recording system. Ann Allergy Asthma Immunol. 2012, 108(3), 167–71.
- Fisher M. M., Bowey C. J. Alleged allergy to local anaesthetics. Anaesth Intensive Care. 1997, 25, 611–614.
- Pirmohamed M., Ostrov D. A., Park B. K. New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity. J Allergy Clin Immunol. 2015, 136(2), 236–244.
- Hoffmann H. J., Santos A. F., Mayorga C., Nopp A., Eberlein B., Ferrer M., Rouzaire P., Ebo D. G., Sabato V., Sanz M. L., Pecaric-Petkovic T., Patil S. U., Hausmann O., Shreffler W. G., Korosec P., Knol E. F. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. 2015, 70, 1393–1405.
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