CONTRIBUTION OF DIFFERENT TYPES OF MELATONINE RECEPTORS TO HORMONE-DEPENDENT REGULATION OF T LYMPHOCYTES PRODUCING IL-17 (TH17) DIFFERENTIATION
- Authors: Glebezdina N.S.1, Nekrasova I.V.1, Olina A.A.2, Sadykova G.K.3
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Affiliations:
- IEGM UB RAS
- D.О. Ott Research Institute of Obstetrics, Gynecology and Reproductology
- Perm State Medical University named after E. A. Wagner of the Ministry of Healthcare of the Russian Federation
- Issue: Vol 22, No 2-2 (2019)
- Pages: 751-753
- Section: ORIGINAL ARTICLES
- URL: https://ogarev-online.ru/1028-7221/article/view/119489
- DOI: https://doi.org/10.31857/S102872210006713-9
- ID: 119489
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Abstract
The involvement of different types of melatonin receptors in hormone-dependent regulation of the differentiation of T helpers producing IL-17 (Th17) was studied. It has been shown that in low physiological concentrations melatonin realized effects through membrane receptors, whereas the action of the hormone’s pharmacological concentrations was mediated by both membrane and nuclear receptors and was dose dependent.
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About the authors
N. S. Glebezdina
IEGM UB RAS
Author for correspondence.
Email: glebezdina_n@mail.ru
PhD, Junior Researcher, Laboratory of Immunoregulation,
Perm
Russian FederationI. V. Nekrasova
IEGM UB RAS
PhD, Researcher, Laboratory of Immunoregulation,
Perm
Russian FederationA. A. Olina
D.О. Ott Research Institute of Obstetrics, Gynecology and Reproductology
DMedSc, Deputy Director for Development,
Perm
Russian FederationG. K. Sadykova
Perm State Medical University named after E. A. Wagner of the Ministry of Healthcare of the Russian Federation
PhD, Assistant Professor of the Department of Obstetrics and Gynecology,
Perm
Russian FederationReferences
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