Chronic inflammation and stress-hormones: a common pathway of cognitive disorders in ageing
- Authors: Filippova Y.Y.1, Burmistrova A.L.1
-
Affiliations:
- Chelyabinsk State University
- Issue: Vol 23, No 3 (2020)
- Pages: 303-308
- Section: SHORT COMMUNICATIONS
- URL: https://ogarev-online.ru/1028-7221/article/view/119460
- DOI: https://doi.org/10.46235/1028-7221-320-CIA
- ID: 119460
Cite item
Full Text
Abstract
Here we present the data on examining inter-connections cytokine network and stress hormones in senile vascular dementia by assessing systemic cytokine levels for IL-1β, IL-6, IL-10, TNFα, IFNγ as well as hormones cortisol, adrenocorticotropic hormone (ACTH), epinephrine, norepinephrine and dopamine in 23 subjects with vascular dementia and 40 individuals without overt cognitive impairment. It was found, that the concentrations of IL-6, TNFα, epinephrine and dopamine were significantly increased, whereas those for IL-1β, IL-10, ACTH and norepinephrine were decreased in elderly people with dementia compared to healthy aging. In addition, virtually no inter-connection between cytokine, sympathoadrenal and hypothalamicpituitary (HPA-axis) axis was observed in vascular dementia highlighted by no significant correlation within the cytokine network. However, a single positive intrahormonal link for cortisol-ACTH and two positive links between IFNγ and cortisol/adrenaline level were detected. In general, vascular dementia was featured by marked inflammatory reaction, excessive activation of stress hormone production and disconnection of cytokine network, HPA-axis and the sympathoadrenal medullary system.
Keywords
About the authors
Yu. Yu. Filippova
Chelyabinsk State University
Author for correspondence.
Email: julse@rambler.ru
Filippova Yuliya Yu. - PhD (Biology), Associate Professor, Department of Microbiology, Immunology and General Biology, Faculty of Biology
454001, Chelyabinsk, Br. Kashirin str., 129
Phone: 7 (351) 799-71-76
Russian FederationA. L. Burmistrova
Chelyabinsk State University
Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Head, Department of Microbiology, Immunology and General Biology, Faculty of Biology
Chelyabinsk
Russian FederationReferences
- Филиппова Ю.Ю., Бурмистрова А.Л, Когнитивная ось старости: воспаление – микробиота тонкого кишечника // Журнал микробиологии, эпидемиологии и иммунобиологии, 2017. № 5. С. 3-9. [Filippova Yu.Yu., Burmistova A.L. Cognitive axis of ageing: inflammation – microbiota of small intestine. Zhurnal mikrobiologii epidemiologii i immunologii = Journal of Microbiology, Epidemiology and Immunobiology, 2017, Vol. 5, pp. 3-9. (In Russ.)]
- Archer T. BDNF integrity in ageing and stress. MOJ Gerontology & Geriatrics, 2017, Vol. 1, no. 6, pp. 155-158.
- Baruch K., Deczkowska A., David E., Castellano J.M., Miller O., Kertser A., Berkutzki T., Barnett-Itzhaki Z., Bezalel D., Wyss-Coray T., Amit I., Schwartz M. Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science, 2014, Vol. 346, pp. 89-93.
- Belkhelfa M., Rafa H., Medjeber O., Arroul-Lammali A., Behairi N., Abada-Bendib M., Makrelouf M., Belarbi S., Masmoudi A.N., Tazir M., Touil-Boukoffa C. IFN-γ and TNF-α are involved during Alzheimer disease progression and correlate with nitric oxide production: a study in Algerian patients. J. Interferon Cytokine Res., 2014, Vol. 34, no. 11, pp. 839-847.
- Chrousos G.P. Stress, chronic inflammation, and emotional and physical well-being: concurrent effects and chronic sequelae. J. Allergy Clin. Immunol., 2000, Vol. 106, pp. S275-S291.
- Enciu A.M., Popescu B.O. Is there a causal link between inflammation and dementia? Biomed. Res. Int., 2013, 316495. doi: 10.1155/2013/316495.
- Galic M.A., Riazi K., Pittman Q.J. Cytokines and brain excitability. Front. Neuroendocrinol., 2012, Vol. 33, no. 1, pp. 116-125.
- Gannon M., Che P., Chen Y., Jiao K., Roberson E.D, Wang Q. Noradrenergic dysfunction in Alzheimer’s disease. Front. Neurosci., 2015, Vol. 9, 220. doi: 10.3389/fnins.2015.00220.
- Goshen I., Kreisel T., Ounallah-Saad H., Renbaum P., Zalzstein Y., Ben-Hur T., Levy-Lahad E., Yirmiya R. A dual role for interleukin-1 in hippocampal-dependent memory processes. Psychoneuroendocrinology, 2007, Vol. 32, no. 8-10, pp. 1106-1115.
- Herrmann N., Lanctôt K.L., Khan L.R. The role of norepinephrine in the behavioral and psychological symptoms of dementia. J. Neuropsychiatry Clin. Neurosci., 2004, Vol. 16, no. 3, pp. 261-276.
- Mausbach B.T., Aschbacher K., Mills P.J., Roepke S.K., von Känel R., Patterson T.L., Dimsdale J.E., Ziegler M.G., Ancoli-Israel S., Grant I. A 5-year longitudinal study of the relationships between stress, coping, and immune cell beta (2)-adrenergic receptor sensitivity. Psychiatry Res., 2008, Vol. 160, pp. 247-255.
- Ouanes S., Popp J. High Cortisol and the risk of dementia and Alzheimer’s disease: a review of the literature. Front. Aging Neurosci., 2019, Vol. 11, 43. doi: 10.3389/fnagi.2019.00043.
- Scheiblich H., Trombly M., Ramirez A., Heneka M.T. Neuroimmune connections in aging and neurodegenerative diseases. Trends Immunol., 2020, Vol. 41, no. 4, pp. 300-312.
- Wang L.Y., Raskind M.A., Wilkinson C.W., Shofer J.B., Sikkema C., Szot P., Quinn J.F., Galasko D.R., Peskind E.R. Associations between CSF cortisol and CSF norepinephrine in cognitively normal controls and patients with amnestic MCI and AD dementia. Int. J. Geriatr. Psychiatry, 2018, Vol. 33, no. 5, pp. 763-768.
- Yiallouris A., Tsioutis C., Agapidaki E., Zafeiri M., Agouridis A.P., Ntourakis D., Johnson E.O. Adrenal aging and its implications on stress responsiveness in humans. Front. Endocrinol. (Lausanne), 2019, Vol. 10, 54. doi: 10.3389/fendo.2019.00054.
- Zhang B, Zhang Y, Xu T, Yin Y., Huang R., Wang Y., Zhang J., Huang D., Li W. Chronic dexamethasone treatment results in hippocampal neurons injury due to activate NLRP1 inflammasomein vitro.Int. Immunopharmacol. 2017, Vol. 49, pp. 222-230.
Supplementary files
