Мақаланы E-mail арқылы жіберу Analysis of the Relationship between the Concentration of Neurotransmitters and Tau Protein in the Brain of Animals with Chronic Traumatic Encephalopathy
- Авторлар: Pozdnyakov D.I.1,2, Kharitonova O.V.1, Burzhumova D.R.1, Efremova M.P.1
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Мекемелер:
- Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of Russia
- “Pyatigorsk State Research Institute of Balneology” branch of the Federal State Budgetary Institution “Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency”
- Шығарылым: Том 42, № 3 (2025): VOL 42, NO3 (2025) Diversity of Neuroregulatory Processes (on the 100th Anniversary of I.P. Ashmarin) (Special Issue, Part 1)
- Беттер: 503–508
- Бөлім: Regular Articles. Experimental Articles
- URL: https://ogarev-online.ru/1027-8133/article/view/382048
- DOI: https://doi.org/10.7868/S3034556125030178
- ID: 382048
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
Chronic traumatic encephalopathy is a progressive neurodegenerative pathology characterized by tau protein accumulation and characteristic clinical symptoms that may be mediated by neurotransmitter disorders. The aim of the study. To evaluate the relationship between the concentration of neurotransmitters and tau protein in the cerebral cortex and hippocampus of rats with chronic traumatic encephalopathy. Pathology was modeled in Wistar rats. The levels of dopamine, glutamate, serotonin, GABA, glycine, acetylcholine, and tau protein were assessed in the hippocampus and cerebral cortex. It was found that in rats with chronic traumatic encephalopathy, the content of tau protein in the cerebral cortex and hippocampus increased by 27.5 times (p < 0.05) and 14.1 times (p < 0.05). There was also an increase in the levels of dopamine and glutamate, while the concentrations of serotonin, GABA, glycine and acetylcholine, on the contrary, decreased both in the hippocampus and in the cerebral cortex. Regression analysis revealed that the highest correlation is between the concentration of tau protein and glutamate (r2 = 0.9420 for the cerebral cortex and r2 = 0.9664 for the hippocampus).
Негізгі сөздер
Авторлар туралы
D. Pozdnyakov
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of Russia; “Pyatigorsk State Research Institute of Balneology” branch of the Federal State Budgetary Institution “Federal Scientific and Clinical Center for Medical Rehabilitation and Balneology of the Federal Medical and Biological Agency”
Email: pozdniackow.dmitry@yandex.ru
Pyatigorsk, Russia; Pyatigorsk, Russia
O. Kharitonova
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of RussiaPyatigorsk, Russia
D. Burzhumova
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of RussiaPyatigorsk, Russia
M. Efremova
Pyatigorsk Medical and Pharmaceutical Institute – branch of the Volgograd State Medical University of the Ministry of Health of RussiaPyatigorsk, Russia
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