Physiological Effects of Modified Obestatin Analogues in Rats

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

Today the problem of regulating eating behavior is becoming increasingly relevant due to the spread of obesity and related comorbid diseases. Obesity increases the risk of many cardiovascular, respiratory and musculoskeletal diseases also accompanied by emotional disorders and the development of depressive states, which reduces life quality and duration. Endogenous peptide regulators, in particular obestatin and its derivatives, often appear among potential pharmacological correctors of body weight and eating behavior. The effects of course intranasal administration of two modified obestatin 1-4 (FNAP) fragments on body weight, feed and water intake, as well as on number of physiological parameters of functional body state were analyzed in order to assess the potential value of fragments studied as a basis for anorexic regulators creation. It was shown that anorexigenic effect of the hexapeptide FNAPEP-NH2is due to a decrease in feed intake, in addition, the peptide had anxiolytic and analgesic effects and led to a decrease in locomotor activity of experimental animals. A decrease in body weight caused by longer FNAPVEP-NH2 fragment was manifested without changes in food and water intake and was not accompanied by changes in spontaneous behavior, anxiety level and pain threshold, making this particular fragment preferable as a basis for eating behavior regulators creation.

Авторлар туралы

A. Maklakova

Lomonosov Moscow State University

Moscow, Russia

M. Maslova

Lomonosov Moscow State University

Moscow, Russia

A. Graf

Lomonosov Moscow State University

Email: grafav@my.msu.ru
Moscow, Russia

Әдебиет тізімі

  1. Favieri F., Tambelli R., Chen E., Casagrande M. // Nutrients. 2024. V. 16. P. 2318–2334.
  2. Lopez R.B., Cruz-Vespa I. // Current Opinion in Behavioral Sciences. 2022. V. 48: P. 101214.
  3. Berner L.A., Brown T.A., Lavender J.M., Lopez E., Wierenga C.E., Kaye W.H. // Mol Cell Endocrinol. 2019. V. 497. P. 110320.
  4. Schalla M.A., Stengel A. // Int. J. Mol. Sci. 2018. V. 19. P. 2117.
  5. De Smet B., Thijs T., Peeters T.L., Depoortere I. // Neurogastroenterol. Motil. 2007. V. 19. P. 211–217.
  6. Depoortere I., Thijs T., Moechars D., De Smet B., Ver Donck L., Peeters T.L. // Br J. Pharmacol. 2008. V. 153. P. 1550–1557.
  7. Lucka A, Wysokiński A. // Ch. J. Physiol. 2019. V. 62. P. 217.
  8. Dutkiewicz A., Tyszkiewicz-Nwafor M., Bilska K., Paszyńska E., Roszak M., Zwolińska W., Pytlińska N., Słopień A., Dmitrzak-Węglarz M. // Psychiatry Int. 2022. V. 3. P. 248–263.
  9. Uehara M., Yasuhara D., Nakahara T., Harada T., Koyama K.I., Ushikai M., Asakawa A., Inui A. // Exp. Clin. Endocrinol. Diabetes. 2011. V. 119. P. 536–539.
  10. Germain N., Galusca B., Grouselle D., Frere D., Billard S., Epelbaum J., Estour B. // J. Clin. Endocrinol. Metab. 2010. V. 95. P. 3057–3062.
  11. Villarrea D., Pradhan G., Zhou Y., Xue B., Sun Y. // Biomolecules. 2022. V. 12. P. 517.
  12. Shen C., Yu T., Tang Z.H., Wu K.M. // Horm. Res. Paediatr. 2013. V. 79. P. 341–346.
  13. Moran B.M., Miskelly M.G., Abdel-Wahab Y.H.A., Flatt P.R., McKillop A.M. // Bio.l Chem. 2019. V. 400. P. 1023–1033.
  14. Granata R., Volante M., Settanni F., Gauna C., Ghé C., Annunziata M., Deidda B., Gesmundo I., Abribat T., van der Lely A.J., Muccioli G., Ghigo E., Papotti M. // J. Mol. Endocrinol. 2010. V. 45. P. 9–17.
  15. Reano S., Angelino E., Ferrara M., Malacarne V., Sustova H., Sabry O., Agosti E., Clerici S., Ruozi G., Zentilin L., Prodam F., Geuna S., Giacca M., Graziani A., Filigheddu N. // Stem Cells. 2017. V. 35. P. 1733–1746.
  16. Green B.D., Irwin N., Flatt P.R. // Peptides. 2007. V. 28. P. 981–987.
  17. Nagaraj S., Peddha M.S., Manjappara U.V. // Biochem. Biophys. Res. Commun. 2008. V. 366. P. 731–737.
  18. Subasinghage A.P., Green B.D., Flatt P.R., Irwin N., Hewage C.M. // Peptides. 2010. V. 31. P. 1697–1705.
  19. Khirazova E.E., Motorykina E.S., Maslova M.V., Maklakova A.S., Graf A.V., Sokolova N.A., Kamenskii A.A // Bull. Exp. Biol. Med. 2017. V. 163. P. 293–295.
  20. Green B.D., Grieve D.J. // Peptides. 2018. V. 100. P. 249–259.
  21. Ашмарин И.П., Незавибатько В.Н., Мясоедов Н.Ф., Каменский А.А., Гривенников И.А., Пономарева-Степная М.А., Андреева Л.А., Каплан А.Я., Кошелев В.Б., Рясина Т.В. // Журнал ВНД. 1997. Т. 47. С. 420–430.
  22. Pietrowsky R., Struben C., Molle M., Fehm H.L., Born J. // Biol. Psychiatry. 1996. V. 39. P. 332–340.
  23. Baevsky R.М., Chernikova A.G. // Cardiometry. 2017. № 10. P. 66–76.
  24. Хиразова Е.Э., Маслова М.В., Моторыкина Е.С., Фрид Д.А., Граф А.В., Маклакова А.С. // Доклады Академии наук. 2013. Р. 350.
  25. Alén B.O., Nieto L., Gurriarán-Rodríguez U., Mosteiro C.S., Álvarez-Pérez J.C., Otero-Alén M., Camiña J.P., Gallego R., García-Caballero T., Martín-Pastor M., Casanueva F.F., Jiménez-Barbero J., Pazos Y. // PLoS One. 2012. V. 7. P. 45434.
  26. Gurriarán-Rodríguez U., Santos-Zas I., González-Sánchez J., Beiroa D., Moresi V., Mosteiro C.S., Lin W., Viñuela J.E., Señarís J., García-Caballero T., Casanueva F.F., Nogueiras R., Gallego R., Renaud J.M., Adamo S., Pazos Y., Camiña J.P. // Mol. Ther. 2015. V. 23. P. 1003–1021.
  27. Szlis M., Polkowska J., Skrzeczyńska E., Przybył B.J., Wójcik-Gładysz A. // J. Anim. Physiol. Anim. Nutr. (Berl). 2018. V. 102. P. 690–700.
  28. Granata R., Settanni F., Gallo D., Trovato L., Biancone L., Cantaluppi V., Nano R., Annunziata M., Campiglia P., Arnoletti E., Ghè C., Volante M., Papotti M., Muccioli G., Ghigo E. // Diabetes. 2008. V. 57. P. 967–979.
  29. Gargantini E., Lazzari L., Settanni F., Taliano M., Trovato L., Gesmundo I., Ghigo E., Granata R. // Mol. Cell Endocrinol. 2016. V. 422. P. 18–30.
  30. Pradhan G., Wu C.S., Han Lee J. // Sci. Rep. 2017. V. 7. P. 979.
  31. Ataka K., Inui A., Asakawa A., Kato I., Fujimiya M. // Am. J. Physiol. Gastrointest. Liver Physiol. 2008. V. 294. P. G1210–1218.
  32. Szakács J., Csabafi K., Lipták N., Szabó G. // Behav. Brain Res. 2015. V. 293. P. 41–45.
  33. Daina A., Michielin O., Zoete V. // Sci. Rep. 2017. V. 7. Р. 42717.
  34. Rybnikova E.A., Pelto-Huikko M., Rakitstaya V.V., Shalyapina V.G. // Neurosci. Behav. Physiol. 2003. V. 33. P. 399–404.
  35. Gehlert D.R., Shekhar A., Morin S.M., Hipskind P.A., Zink C., Gackenheimer S.L., Shaw J., Fitz S.D., Sajdyk T.J. // Eur. J. Pharmacol. 2005. V. 509. P. 145–153.
  36. Miguel T.T., Nunes-de-Souza R.L. // Horm. Вehav. 2011. V. 60. P. 292–300.
  37. Chen L., Wu H., Li Y., Feng X., Zhu S., Xie K., Wu X., Sun Z., Shu G., Wang S., Gao P., Zhu X., Zhu C., Jiang Q., Wang L. // Biochem. Biophys. Res. Commun. 2022. V. 602. P. 77–83.
  38. Yarushkina N.I., Bagaeva T.R., Filaretova L.P. // J. Physiol. Pharmacol. 2016. V. 67. P. 595–603.
  39. Hauger R.L., Risbrough V., Brauns O., Dautzenberg F.M. // Neurol. Disord. Drug Targets. 2006. V. 5. P. 453–479.
  40. Fujimiya M., Ataka K., Asakawa A., Chen C.Y., Kato I., Inui A. // Digestion. 2012. V. 85. P. 90–94.
  41. Motorykina E.S., Khirazova E.E., Maslova M.V., Maklakova A.S., Graf A.V., Bayzhymanov A.A., Kurko O.D., Zamyatina L.A., Andreyeva L.A., Sokolova N.A., Myasoyedov N.F., Kamenskii A.A. // Dokl. Biol. Sci. 2015. V. 460. P. 1–4.
  42. Farkas E., Szilvásy-Szabó A., Ruska Y., Sinkó R., Rasch M.G., Egebjerg T., Pyke C., Gereben B., Knudsen L.B., Fekete C. // Brain Struct. Funct. 2021. V. 226. P. 225–245.
  43. Singh I., Wang L., Xia B., Liu J., Tahiri A., El Ouaamari A., Wheeler M.B., Pang Z.P. // Cell Biosci. 2022. V. 12. P. 178.
  44. Banks W.A., During M.J., Niehoff M.L. // J. Pharmacol. Exp. Ther. 2004. V. 309. P. 469‒475.
  45. Mitchell C.S., Premaratna S.D., Bennett G., Lambrou M., Stahl L.A., Jois M., Barber E., Antoniadis C.P., Woods S.C., Cameron-Smith D., Weisinger R.S., Begg D.P. // Front. Endocrinol. 2021. V. 12. P. 682726.
  46. Santos E.L., de Picoli Souza K., Guimarães P.B., Reis F.C., Silva S.M., Costa-Neto C.M., Luz J., Pesquero J.B. // Int. Immunopharmacol. 2008. V. 8. P. 247–253.
  47. Weisinger R.S., Begg D.P., Chen N., Jois M., Mathai M.L., Sinclair A.J. // Asia Pac. J. Clin. Nutr. 2007. V. 16 Suppl. 1. P. 359–367.
  48. Weisinger R.S., Begg D.P., Jois M. // Curr. Opin. Investig. Drugs. 2009. V. 10. P. 1069–1077.
  49. Dong J., Wang N.N., Yao Z.J., Zhang L., Cheng Y., Ouyang D. // J. Cheminform. 2018. V. 10. Р. 29.

Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу

© Russian Academy of Sciences, 2025

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).