Outlooks of Using Small Extracellular Vesicles as a Transport Vehicle through the Blood–Brain Barrier

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Abstract

The review summarizes the results of recent studies on the mechanisms mediating the crossing by small extracellular vesicles through blood-brain barrier (BBB). The kinds of vesicular transport through the BBB, including receptor-mediated and adsorptive-mediated transcytosis, are considered. The possibilities of optimizing the penetration of vesicles into the parenchyma of the brain through the BBB are shown.

About the authors

L. G. Khaspekov

Research Center of Neurology

Email: nchjournal@gmail.com
Russia, Moscow

A. A. Yakovlev

Institute of Higher Nervous Activity and Neurophysiology RAS; Scientific and Practical Psychoneurological Center named after Z.P. Solovy’ov DZM

Email: nchjournal@gmail.com
Russia, Moscow; Russia, Moscow

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