Email this article Role of phosphoinositide metabolism in multiple sclerosis pathogenesis
- Authors: Gerasimova М.М.1, Menshikova Т.V.1
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Affiliations:
- Tver State Medical Academy
- Issue: Vol XXX, No 3-4 (1998)
- Pages: 27-29
- Section: Articles
- URL: https://ogarev-online.ru/1027-4898/article/view/81033
- DOI: https://doi.org/10.17816/nb81033
- ID: 81033
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Abstract
Phosphoinositides in lymphocytes and machrophages in 20 patients with multiple sclerosis have been studied with the help of highly effective liquid and thin-layer chromatography. In all patients phosphoinositide metabolism inpairment was revealed, which can be caused both by impairment of phosphoinositide response of immunocompetent cells, and by connecting myelin with consequent demyelinization. The revealed fact may serve one of criteria of demyelinizathion process activity, and also evidences the certain role of the revealed impairment in multiple sclerosis pathogenesis.
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##article.viewOnOriginalSite##About the authors
М. М. Gerasimova
Tver State Medical Academy
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Tver
Т. V. Menshikova
Tver State Medical Academy
Email: info@eco-vector.com
Russian Federation, Tver
References
- Бышевский А.Ш., Терсенов О.А. Биохимия для врача. — Екатеринбург, 1994.
- Матвеева Т.В., Дьяконова И.Н., Пилле Э.Р. // Советская медицина. — 1981. - № 4. — С. 22 — 26.
- Слюсарь Н.Н. Роль фосфоинозитидов и их метаболитов в онкогенезе: Автореф. дисс. ... докг. мед. наук. — Москва, 1992.
- Хондкариан О.А., Завалишин И.А., Невская О.М. Рассеяный склероз. — М., 1993.
- Марри Р., Греннер Д., Мейес П., Родуэлл В. Биохимия человека. — М., 1993. — Т. 2
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