Small dosages of ionizing radiation as a risk factor of systemic osteoporosis
- Authors: Rodionova S.S.1,2,3, Shvets V.N.1,2,3, Ilyina V.K.1,2,3, Burdygin V.N.1,2,3, Meerson Y.M.1,2,3, Rozhinskaya L.Y.1,2,3
-
Affiliations:
- Central Institute of Traumatology and Orthopedics. N.N. Priorov
- Research and Production Center for Medical Biotechnology
- Endocrinology Research Center
- Issue: Vol 2, No 1-2 (1995)
- Pages: 21-26
- Section: Original study articles
- URL: https://ogarev-online.ru/0869-8678/article/view/99574
- DOI: https://doi.org/10.17816/vto99574
- ID: 99574
Cite item
Full Text
Abstract
Biopsy specimens from the wing of the ilium were examined in 16 liquidators of the Chernobyl Atomic Power Station accident. A test for clonogenic stromal cells was performed long with quantitative analysis of osseous tissue parameters and the histomorphometric assessment of remodelling processes (resorption and osteogenesis). There was strong evidence for the fact that small dose ionizing radiation might lead to the development of at least 3 types of osseous tissue metabolic disturbances: osteoporosis of the cortical bone; that of the cortical and spongy bones (the mixed type) and abnormalities arbitrarily defined as osteosclerosis. It was found that resorption was simultaneously or even before suppressed in osteoporosis in the liquidators, whereas in other forms of osteoporosis, inhibited ostepgenesis triggerred rarefaction of the bones. The negative effect of ionizing radiation on stromal cells of the bone marrow was evident by the studies of the efficiency of cloning of osteoblast precursors. No dependence of the revealed changes on the dosage of ionizing radiation and the various pattern of metabolic disturbances in the osseous tissue under the action of the same dosages suggest that a premorbid background is of definite value in the development of abnormalities.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
S. S. Rodionova
Central Institute of Traumatology and Orthopedics. N.N. Priorov; Research and Production Center for Medical Biotechnology; Endocrinology Research Center
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
V. N. Shvets
Central Institute of Traumatology and Orthopedics. N.N. Priorov; Research and Production Center for Medical Biotechnology; Endocrinology Research Center
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
V. K. Ilyina
Central Institute of Traumatology and Orthopedics. N.N. Priorov; Research and Production Center for Medical Biotechnology; Endocrinology Research Center
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
V. N. Burdygin
Central Institute of Traumatology and Orthopedics. N.N. Priorov; Research and Production Center for Medical Biotechnology; Endocrinology Research Center
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
Y. M. Meerson
Central Institute of Traumatology and Orthopedics. N.N. Priorov; Research and Production Center for Medical Biotechnology; Endocrinology Research Center
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
L. Y. Rozhinskaya
Central Institute of Traumatology and Orthopedics. N.N. Priorov; Research and Production Center for Medical Biotechnology; Endocrinology Research Center
Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow; Moscow; Moscow
References
- Анализ заболеваемости участников ликвидации последствий аварии на Чернобыльской атомной электростанции по Ростов. области за 1990—1992 гг.: Информ. письмо. — Ростов н/Д, 1992.
- Бриллиант М.Д., Воробьев А.И., Гогин Е.Е. //Тер. арх. — 1987. — N 6. — С. 3—8.
- Владимиров В.Г. // Воен.-мед. журн. — 1989. — N 4. — С. 44—46.
- Гуськова А.К. //Мед. радиол. — 1989. — N 10. — С. 83—85.
- Гущ В.В., Смирнов Н.А., Прокопчук Б.М. // Воен.-мед. журн. — 1993. — N 10. — С. 45—51.
- Ильин Л.А., Балонов М.И. //Мед. радиол. — 1989. — N 11. — С. 59—81.
- Кон Р.И., Рот К.С. Ранняя диагностика нарушений обмена веществ. — М., 1986.
- Пяткин Е.К. // Гематол. и трансфузиол. — 1985. — Т. 30, N 3. — С. 50—59.
- Родионова С.С. //Ортопед. травматол. — 1991. — N 8. — С. 34—38.
- Родионова С.С. Метаболические остеопатии: системный остеопороз и остеомаляция у взрослых: Автореф. дис. ... д-ра мед. наук. — М., 1992.
- Ташкэ К. Введение в количественную цитологическую морфологию. — Бухарест, 1980. — С. 76—86.
- Тондрия Т.В. // Радиобиология. — 1985. — Т. 25, вып. 1. — С. 83—86.
- Швец В.Н., Панкова А.С. //Там же. — С. 108—111.
- Fridenstein A., Latsimik N. et al. //Exp. Hemat. — 1982.
- — Vol. 10. — P. 217—227.
- Merz W., Schenk R. //Acta anat. (Basel). — 1970. — Vol. 76. — P. 1—15.
- Nicolson G.L. //Cancer Res. — 1987. — Vol. 47, N 6. — P. 1473—1482.
Supplementary files
