Enviar artigo por via de e-mail Engineering recombinant proteins: from structure to function and biological activity
- Autores: Dolgikh D.A1,2
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Afiliações:
- Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
- Lomonosov Moscow State University
- Edição: Nº 7 (2025)
- Páginas: 55-60
- Seção: Review
- URL: https://ogarev-online.ru/0869-5873/article/view/305218
- DOI: https://doi.org/10.31857/S0869587325070063
- EDN: https://elibrary.ru/fiirks
- ID: 305218
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Resumo
The article discusses the development of recombinant protein engineering, primarily artificial proteins or de novo proteins, from the creation of the first proteins with a given spatial structure and biological activity to modern work in this area, which widely uses machine learning and artificial intelligence methods. The use of these methods, in particular the Rozetta and AlphaFold computer platforms, has led to tremendous progress in this area, as evidenced by last year’s Nobel Prize in Chemistry. Currently, these methods should be recommended for use in any modern laboratory conducting work on the physical chemistry of proteins and protein engineering.
Sobre autores
D. Dolgikh
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS; Lomonosov Moscow State University
Email: dolgikh@nmr.ru
Moscow, Russia; Moscow, Russia
Bibliografia
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