The Interaction of Aroylpyruvic Acids with 3- and 4-Nitrobenzohydrazides. Synthesis of Pyrazoline-5-Carboxylic Acids

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Abstract

4-Aryl-2,4-dioxobutanoic acids react with 3-nitro- and 4-nitrobenzohydrazides in a 1:2 ratio to form the corresponding 3-aryl-1-(3-nitrobenzoyl)-5-(2-(3-nitrobenzoyl)hydrazinyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acids and 3-aryl-1-(4-nitrobenzoyl)-5-(2-(4-nitrobenzoyl)hydrazinyl)-4,5-dihydro-1H-pyrazole-5-carboxylic acids, the structure of which is confirmed by X-ray diffraction analysis. The reaction proceeds under mild conditions with high yields without the use of catalysts and additives, and the isolation process does not require column chromatography. The obtained compounds are promising in terms of the manifestation of various types of biological activity.

About the authors

A. A Andreeva

Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences – Branch of the Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences; Perm State National Research University

Email: koh2@psu.ru
ORCID iD: 0000-0003-0665-6273
Perm, Russia; Perm, Russia

Yu. V Shklyaev

Institute of Technical Chemistry, Ural Branch of the Russian Academy of Sciences – Branch of the Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences

Email: koh2@psu.ru
ORCID iD: 0000-0001-7016-1190
Perm, Russia

A. N Maslivets

Perm State National Research University

Author for correspondence.
Email: koh2@psu.ru
ORCID iD: 0000-0001-7148-4450
Perm, Russia

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