Non-Catalytic Synthesis of 5-(4-Cycloalkylamino)Phenyl(bi)pyridines

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Abstract

The possibility of non-catalytic ipso-substitution of the halogen atom in the para-position of the phenyl substituent in the C6 position of the 1,2,4-triazine ring by a cycloalkylamine group in the absence of a solvent was investigated. The possibility of transforming the obtained 1,2,4-triazines into the corresponding (bi)pyridines using the Bodger reaction with 2,5-norbornadiene under elevated pressure (using autoclave technology) was shown.

About the authors

S. E Vatolina

Ural Federal University

Yekaterinburg, Russia

A. P Krinochkin

Ural Federal University; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Yekaterinburg, Russia; Yekaterinburg, Russia

T. A Tseytler

Ural Federal University; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Email: t.a.tceytler@urfu.ru
Yekaterinburg, Russia

A. A Yurtaeva

Ural Federal University

Yekaterinburg, Russia

A. S Alekseeva

Ural Federal University

Yekaterinburg, Russia

A. S Markina

Ural Federal University

Yekaterinburg, Russia

V. S Gaviko

Ural Federal University; Institute of Physics of Metals, Ural Branch of the Russian Academy of Sciences

Yekaterinburg, Russia; Yekaterinburg, Russia

D. S Kopchuk

Ural Federal University; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Yekaterinburg, Russia; Yekaterinburg, Russia

G. V Zyryanov

Ural Federal University; Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences

Yekaterinburg, Russia; Yekaterinburg, Russia

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