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A New Bicyclic Pyrrolidine Block for Nirmatrelvir and Analogues
- Authors: Sunagatullina G.R1, Shavaleeva G.A1, Valiullina Z.R1, Miftakhov M.S1
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Affiliations:
- Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
- Issue: Vol 61, No 8 (2025)
- Pages: 1197-1202
- Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
- URL: https://ogarev-online.ru/0514-7492/article/view/376590
- DOI: https://doi.org/10.7868/S3034630425080148
- ID: 376590
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Abstract
To study the chemical properties and potential use in the synthesis of Nirmatrelvir and related compounds, a key block, ((1R,5S))-2-ethoxy-6,6-dimethyl-3-azabicyclo[3.1.0]hex-2-ene, which is readily available from (+)-3-carene and obtained by "enol-ethylation" of ((1R,5S))-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2-one with triethyloxonium tetrafluoroborate ((Et3O)+BF4 –), was proposed.
Keywords
About the authors
G. R Sunagatullina
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
Email: gsunagatullina95@mail.ru
Ufa, Russia
G. A Shavaleeva
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of SciencesUfa, Russia
Z. R Valiullina
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of SciencesUfa, Russia
M. S Miftakhov
Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of SciencesUfa, Russia
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