Synthesis and Antihypoxic Properties of New Derivatives 1,4-Benzodioxanil-1,3,4-oxadiazole

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Resumo

Condensation of previously synthesized 1,4-benzodioxane-2-carboxylic acid hydrazide with chloranhydrides of various arylcycloalkane-, as well as aerylterrahydropyrancarboxylic acids substituted in the aromatic ring, gave N,N′-diacyl-substituted hydrazines, which are cyclized under the action of phosphorus oxychloride to the corresponding 1,3,4-oxadiazolebenzodioxanes. The antihypoxic properties of the synthesized compounds were studied.

Sobre autores

S. Vartanyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0003-4582-7629
Yerevan, Armenia

A. Avakyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: avaga@mail.ru
ORCID ID: 0000-0002-7148-3666
Yerevan, Armenia

A. Sargsyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0001-7115-9164
Yerevan, Armenia

G. Panosyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Yerevan, Armenia

S. Arutyunyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0003-3748-6975
Yerevan, Armenia

G. Gasparyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0002-8555-3733
Yerevan, Armenia

A. Agekyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0001-6151-4951
Yerevan, Armenia

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