Email this article 
New chemical transformation of substituted dinitroacetonitrilе in the reaction with isoquinoline in presence of dimethylbut-2-indioate
- Authors: Tyrkov A.G.1, Yurtaeva E.A.2
-
Affiliations:
- Astrakhan Tatishchev State University
- Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical University
- Issue: Vol 61, No 2 (2025)
- Pages: 203-207
- Section: Articles
- URL: https://ogarev-online.ru/0514-7492/article/view/304565
- DOI: https://doi.org/10.31857/S0514749225020115
- EDN: https://elibrary.ru/dhgics
- ID: 304565
Cite item
Open Access
Access granted
Subscription Access
Abstract
The reaction of substituted dinitroacetonitrile with isoquinoline in the presence of dimethylbut-2-indioate results in the formation of 1,3-dipolar cycloaddition products – a mixture of diastereomeric dimethyl-2-dinitromethyl-1,1bH-pyrimido[2,1-a]isoquinoline-3,4-dicarboxylates. The obtained compounds can be considered as promising synthons with potential antituberculosis and fungicidal activity.
About the authors
A. G. Tyrkov
Astrakhan Tatishchev State University
Email: tyrkov@rambler.ru
pl. Shaumyana, 1, Astrakhan, 414000 Russia
E. A. Yurtaeva
Pyatigorsk Medical and Pharmaceutical Institute – branch of Volgograd State Medical Universityprosp. Kalinina, 11, Pyatigorsk, 357532 Russia
References
- Ладыжникова Т.Д., Соловьев Н.А., Алтухов К.В., Перекалин В.В. ЖОрХ. 1988, 24, 644–650.
- Тырков А.Г. ЖОрХ. 2002, 38, 1269–1270. [Tyrkov A.G. Russ. J. Org. Chem. 2002, 38, 1218–1219.] doi: 10.1023/A:1020934400960
- Фридман А.Л., Габитов Ф.А., Сурков В.Д. ЖОрХ. 1972, 12, 2457–2463.
- Ладыжникова Т.Д., Тырков А.Г., Соловьев Н.А., Алтухов К.В. ЖОрХ. 1989, 25, 444–445.
- Ладыжникова Т.Д., Алтухов К.В., Соловьев Н.А. ЖОрХ. 1986, 22, 2618–2619.
- Adlu M., Yavari I. Bull. Chem. Soc. Ethiop. 2023, 37, 115–122. doi: 10.4314/bcse.v37iI.10
- Граник В.Г. Основы медицинской химии. М.: Вузовская книга, 2001, 278.
- Parker C., Emmjns W., Rolewicz H., McCallum K. Tetrahedron.1962, 17, 79–87.
- Parker C. Tetrahedron.1962, 17, 109–116.
- Фокин А.В., Галахов В.С., Узун А.Т., Радченко В.П., Столяров В.П. Изв. АН СССР, сер. хим. 1974, 2, 456–458.
- Кирхнер Ю. Тонкослойная хроматография. М.: Мир, 1981, 1, 129, 218.
Supplementary files
