Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata
- Authors: Desheva Y.A.1,2, Smolonogina T.A.1, Doroshenko E.M.1, Rudenko L.G.1
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Affiliations:
- Institute of Experimental Medicine
- St. Petersburg State University
- Issue: Vol 61, No 1 (2016)
- Pages: 16-20
- Section: ORIGINAL RESEARCH
- URL: https://ogarev-online.ru/0507-4088/article/view/118031
- DOI: https://doi.org/10.18821/0507-4088-2016-61-1-16-20
- ID: 118031
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Abstract
This work is devoted to the research of the live attenuated influenza vaccine (LAIV) comprising two reassortant B/USSR/60/69-based vaccine influenza viruses Victoria and Yamagata. the intranasal immunization of the CBA mice with both victoria and yamagata strains induced 100% lung protection against the subsequent infection with the wild-type influenza B viruses of any antigen lineage. the quadrivalent LAIV (qLAIV) comprising both reassortant influenza B viruses Victoria and Yamagata were safe and areactogenic in adult volunteers. Following qLAIV administration the immune response was achieved to both Victoria and Yamagata lineages.
Keywords
About the authors
Yu. A. Desheva
Institute of Experimental Medicine; St. Petersburg State University
Author for correspondence.
Email: desheva@mail.ru
Yuliya Desheva, MD, PhD, DS
197376, St. Petersburg
199034, St. Petersburg
T. A. Smolonogina
Institute of Experimental Medicine
Email: fake@neicon.ru
197376, St. Petersburg Russian Federation
E. M. Doroshenko
Institute of Experimental Medicine
Email: fake@neicon.ru
197376, St. Petersburg Russian Federation
L. G. Rudenko
Institute of Experimental Medicine
Email: fake@neicon.ru
197376, St. Petersburg Russian Federation
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