HEMORRHAGIC FEVER WITH RENAL SYNDROME GROUP OUTBREAK CAUSED BY SOCHI VIRUS

T. K. Dzagurova; Дзагурова Т. К.; A. A. Ishmukhametov; Ишмухаметов А. А.; V. A. Bakhtina; Бахтина В. А.; V. G. Morozov; Морозов В. Г.; M. V. Balovneva; Баловнева М. В.; S. S. Kurashova; Курашова С. С.; B. .. Klempa; Клемпа Б. ..; D. .. Kruger; Кругер Д. ..; E. A. Tkachenko; Ткаченко Е. А.

doi:10.18821/0507-4088-2019-64-1-36-41

HEMORRHAGIC FEVER WITH RENAL SYNDROME GROUP OUTBREAK CAUSED BY SOCHI VIRUS

作者: Dzagurova T.K.¹, Ishmukhametov A.A.¹^,2, Bakhtina V.A.³, Morozov V.G.⁴, Balovneva M.V.¹, Kurashova S.S.¹, Klempa B...⁵, Kruger D...⁶, Tkachenko E.A.¹^,2
隶属关系:
1. Chumakov federal scientific center for research and development of immune-and-biological products of Russian academy of sciences
2. 1th Moscow State medical university named by I.M. Sechenov
3. Specialized clinical infectious hospital
4. Medical Company «Gepatolog»
5. Biomedical Research Center Slovak Academy of Sciences
6. Institute of Virology, Helmut-Ruska-Haus
期: 卷 64, 编号 1 (2019)
页面: 36-41
栏目: ORIGINAL RESEARCH
URL: https://ogarev-online.ru/0507-4088/article/view/118004
DOI: https://doi.org/10.18821/0507-4088-2019-64-1-36-41
ID: 118004

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Introduction. Hemorrhagic fever with renal syndrome (HFRS) occupies a leading place among natural focal human diseases in the Russian Federation. Sporadic incidence of HFRS-Sochi has been annually recorded in the Krasnodar Territory since 2000. The group outbreak of the HFRS-Sochi was first registered in Gelendzhik in the fall of 2013. Material and methods. Serological methods were used: indirect immunofluorescence, enzyme immunoassay, FRNT in Vero cells, and methods for the viral RNA detection: PCR and RT-PCR. Results. Data of clinical, epidemiological, immunological and molecular studies of 3 out of 4 cases in HFRS-Sochi outbreak are presented. Severity of the disease correlated with early gastrointestinal disorders appearance. Patient MA gastrointestinal disorders were joined on day 3 of a fever. Clinical and laboratory studies revealed signs of kidneys, liver, pancreas damage, bilateral hydrothorax, bilateral polysegmental pneumonia and polyneuropathy. As a result of long-term treatment, the patient recovered. Patient AA had gastrointestinal disturbances the next day after fever onset. The patient was not saved, despite early hospitalization. Hantavirus antigen and RNA were detected in the lung tissues 2 out of 10 Black-Sea field mice captured in the affected area, as well as in the organs of deceased patient. Discussion. The most severe clinical course of the disease in close relatives, son and father, with a fatal outcome in the latter case may be the result of genetic features. The severity and outcome of the disease was not depend on day of hospitalization and correlated with the early manifestations of gastrointestinal disorders. Conclusion. Presented data confirm high virulence and pantropism of the Sochi virus, as well as the epidemiological role of Black-Sea field mouse (Apodemus ponticus) as the host of the Sochi virus and the source of human infection.

关键词

hantaviruses, Sochi virus, hemorrhagic fever with renal syndrome, Black-Sea field mouse

参考

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HEMORRHAGIC FEVER WITH RENAL SYNDROME GROUP OUTBREAK CAUSED BY SOCHI VIRUS

全文:

详细

关键词

作者简介

T. Dzagurova

A. Ishmukhametov

V. Bakhtina

V. Morozov

M. Balovneva

S. Kurashova

B. Klempa

D. Kruger

E. Tkachenko

参考

补充文件