Successful Management of Nasal Cavity and Paranasal Sinus Neuroendocrine Carcinoma with Upper Airway Obstruction During Pregnancy: A Case Report

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Abstract

Introduction. Sinonasal neuroendocrine carcinoma is a rare neoplasm with an incidence of 0.2–0.8 %, characterized by an aggressive clinical course. Theco-occurrence of this malignancy with pregnancy has been reported only in isolated clinical cases to date. Case Description. We present a case of stage IV (cT4aN3M0) neuroendocrine carcinoma of the ethmoid bone in a 26-year-old pregnant patient who achieved a complete objective response following EP chemotherapy. Conclusion. The management of malignant neoplasms during pregnancy represents a significant challenge in contemporary oncology, particularly given the increasing incidence of cancer diagnoses during gestation, including rare morphological subtypes.

About the authors

A. M. Konova

Almazov National Medical Research Centre

Email: konovaamix@gmail.com
ORCID iD: 0009-0004-7104-8447
SPIN-code: 6768-5550
St. Petersburg, the Russian Federation

E. Yu. Zorina

Almazov National Medical Research Centre

Email: konovaamix@gmail.com
ORCID iD: 0000-0002-5928-9625
SPIN-code: 3132-7676
St. Petersburg, the Russian Federation

S. S. Sklyar

Polenov Neurosurgical Institute — a branch of the Almazov National Medical Research Centre

Email: konovaamix@gmail.com
ORCID iD: 0000-0002-3284-9688
SPIN-code: 4679-3548
St. Petersburg, the Russian Federation

I. N. Danilov

Almazov National Medical Research Centre

Email: konovaamix@gmail.com
ORCID iD: 0000-0001-9540-7812
SPIN-code: 3267-5056
St. Petersburg, the Russian Federation

E. A. Ulrikh

N.N. Petrov National Medicine Research Center of Oncology; Almazov National Medical Research Centre

Email: konovaamix@gmail.com
ORCID iD: 0000-0002-2701-8812
SPIN-code: 1110-1844
St. Petersburg, the Russian Federation; St. Petersburg

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