Development of technology and study of the microbiological purity of dental gel

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Introduction. The development of herbal medicines is an important part of the pharmaceutical industry. Among the common flavonoid-containing plants there are the herb of knotweed pepper, the herb of knotweed bird and the nettle. From these plants, a liquid extract was obtained for a hemostatic effect.

Objective of the study. To develop a gel technology from local plant raw materials liquid extract and study the microbiological purity.

Material and methods: the object of the study was a dental gel that meets the requirements of regulatory documents. Determination of microbiological purity was carried out in accordance with the methodology of the SP XI edition.

Results. The technology of dental gel from a liquid extract obtained on the basis of local vegetable raw materials was experimentally established.

Conclusion. The data on the substantiation of the composition, technology, the choice of the type and amount of preservative to stabilize the gel in the studied storage period are presented. Study of the antimicrobial, wound-healing properties of dental gel based on liquid extract was carried out.

Sobre autores

Nilufar Rizaeva

Tashkent Research Institute of Vaccines and Serums

Email: nilufar1979@list.ru
ORCID ID: 0000-0002-0529-2896

Candidate of Pharmaceutical Sciences, Associate Professor, Head of the Laboratory of Nutrient Media

Uzbequistão, 37, Chingiz Aytmatov St.,Tashkent, 100084

Nodira Yunuskhojaeva

Tashkent Pharmaceutical Institute

Email: yunusxodjaeva-n@mail.ru
ORCID ID: 0000-0002-5330-8127

Doctor of Pharmaceutical Sciences, Associate Professor, Head of the Organization of Pharmaceutical Production and Quality Management Department

Uzbequistão, 45, Aibek St.,Tashkent, 100015

Rayhona Khusainova

Tashkent Pharmaceutical Institute

Email: xusainova_79@inbox.ru
ORCID ID: 0000-0003-2722-4568

Doctor of Pharmaceutical Sciences, Associate Professor of the Pharmaceutical Chemistry Department

Uzbequistão, 45, Aibek St., Tashkent, 100015

Nigora Yunuskhojieva

Tashkent Pharmaceutical Institute

Autor responsável pela correspondência
Email: nigora.yunuskhojiyeva@gmail.com
ORCID ID: 0000-0002-8897-2909

4th year student

Uzbequistão, 45, Aibek St., Tashkent, 100015

Bibliografia

  1. Berdnik O.G., Rolik S.N., Piminov A.F. Features of the use of soft dosage forms in dentistry. Materials of the IV International Conference. ["Medical and social ecology of personality: state and prospects"]. Minsk, 2006; 78–9 (in Russian).
  2. Parmankulova T.N., Kelimhanova S.E., Satbaeva E.M., Myrzabek B.T., Iskakova M.K., Nurhan SH.A. Development of dental gel with anti-inflammatory and wound healing effect. Vestnik KazNMU. 2017; 2: 298–300 (in Russian).
  3. Savchenko L.N., Marinina T.F., Saushkina A.S., Bondarenko D.A. Development of the composition and technology of dental gel of antimicrobial and local anesthetic action. Materials of the X International Congress "Health and Education in the XXI century". M., 2011; 12: 580–2 (in Russian).
  4. YUnuskhodzhaeva N.A., Sajdalieva F.A., Kazanceva D.S. Hemostatic properties of the collection of medicinal plants of bird's knotweed, pepper knotweed and nettle. Infekciya, immunitet i farmakologiya. 2012; 4: 76–9 (in Russian).
  5. Kavtaradze N.SH., Alaniya M.D. Chromatospectrophotometric method of quantitative determination of vitamin K1 in the leaves of Urtica dioica L. Rast. resources. M., 2002; 38 (4): 118–20 (in Russian).
  6. Nikolaeva G.G., Lavrent'eva M.V., Nikolaeva I.G. Phenolic compounds of various Polygonum species. Chemistry of natures. soedin. Tashkent, 2009; 5: 616–7 (in Russian).
  7. Gubin K.V., Hanina M.A. Study of the chemical composition of the aboveground part of URTICA CANNABINA L. Flora of Siberia. Himiya rast. syr'ya. 2009; 3: 89–92 (in Russian).
  8. Rizaeva N.M., YUnuskhodzhaeva N.A., Gulyamova D.R., YUnuskhozhieva N.E. Development of the composition and technology of dental gel based on liquid extract for the treatment of periodontal diseases. Farmacevticheskij zhurnal. Tashkent, 2022; 3: 58–64 (in Russian).
  9. Shikova YU.V. Biopharmaceutical substantiation of formulations and development of technology for the production of soft dosage forms : abstract. dis. ... doc. pharm. sciences: 15.00.01. Bashkirskij gos. med. un-t. M., 2005; 48. Il. Bibliogr.: s. 10 (in Russian).
  10. Dzholdybaeva A.E., Doszhanova B.A., Batagoeva Z.ZH., Ibadullaeva G.S. Development of the composition and technology of dental gel based on dimethyl sulfoxide with metronidazole for the treatment of traumatic injuries of the oral mucosa. Vestnik KazNMU. 2017; 2: 253–6 (in Russian).
  11. Rizaeva N.M., Vahidova N.M. Development of the composition and technology of dental gel. Vestnik nauki i tvorchestva, Mezhdunarodnyj nauchnyj zhurnal. Kazan', 2017; 5: 109–13 (in Russian).
  12. Hadzhieva Z.D., Kuznecov A.B., Biryukova D.V. Technological aspects of the use of excipients in the production of medicines. Fundamental'nye issledovaniya. 2012; 5–2: 436–40 (in Russian).
  13. TSt 42-01: 2002 "Quality standards of medicines. Basic provisions". Tashkent, 2002; 56 (in Russian).
  14. GF XI Issue 2. Amendment No. 2, Article 193, category 2 (in Russian).

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