Influence of industrial vibration on the level of antibodies against regulatory proteins of the nervous tissue

Resumo

We studied the concentration of antibodies (ABs) to the regulatory proteins of the nervous tissue revealed in the blood serum of healthy men working for a long period of time and of the patients suffering from the vibration-induced disease (VID). A characteristic feature of autoimmune response development in workers who are exposed to vibration for an extensive period of time is the decline in ABs against virtually all examined antigens (AGs), which indicates an overall reduction of immune reactivity in relation to nervous tissue proteins. At the same time, we discovered characteristic changes in certain AB concentrations, both in the spectrum and in the intensity, depending on the severity of a pathologic process. Changes in the AB concentration in long-term workers who do not exhibit signs of any health conditions induced by vibration may indicate nascent changes in the specialized structure of nervous tissue; for VID patients, the presence of changes in the levels of ABs may reflect continuous neuro-destructive processes in nervous tissue.