FROM CELLULAR ARCHITECTURE TO THE REGULATION OF MITOCHONDRIAL FUNCTION: THE ROLE OF VIMENTIN IN ENSURING CELLULAR MITOSTASIS

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Abstract

Mitochondria play a central role in cell physiology, and in addition to performing their primary function as an energy source, they are involved in processes such as regulating intracellular calcium levels, generating reactive oxygen species, synthesizing many critical compounds, regulating apoptosis, and more. In this regard, maintaining them in a normal state is of great importance, ensuring their transport, intracellular distribution, timely biogenesis, and removal of damaged mitochondria from cells. All of this is defined as cellular mitosis, the maintenance of which involves many cellular structures and, primarily, the cytoskeleton. This review summarizes data on the role of one component of the cytoskeleton, vimentin intermediate filaments, in these processes.

About the authors

R. Deeb

Institute of Protein Research of Russian Academy of Sciences; Moscow Institute of Physics and Technology (MIPT)

Pushchino, Russia; Dolgoprudny, Russia

A. S Shakhov

Institute of Protein Research of Russian Academy of Sciences; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

Pushchino, Russia; Moscow, Russia

A. S Churkina

Institute of Protein Research of Russian Academy of Sciences; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

Pushchino, Russia; Moscow, Russia

I. B Alieva

Institute of Protein Research of Russian Academy of Sciences; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University

Pushchino, Russia; Moscow, Russia

A. A Minin

Institute of Protein Research of Russian Academy of Sciences

Email: alexminin@gmail.com
Pushchino, Russia

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