ANTIBIOTICS AND CELLULAR SENESCENCE: AN UNEXPLORED TERRITORY

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Abstract

Antibiotics are certainly the most important agents in the fight against human and animal bacterial infections. The widespread use of antibiotics has a positive impact on the treatment of infectious diseases but may be accompanied by serious side effects. The clinical aspects of these side effects are well understood, but the nonspecific molecular targets are not fully recognized. It is generally known that many antibiotics can damage mitochondria, intracellular organelles responsible for aerobic metabolism as well as regulating a number of important processes, including cellular redox balance and inflammatory responses. Mitochondrial dysfunction commonly leads to the development of oxidative stress and inflammation, known stimuli of cellular senescence. On the other hand, the same stimuli can induce death of senescent cells. Thus, mitotoxic antibiotics may influence both the cellular senescence process and the elimination of senescent cells. The effect of antitumor antibiotics on the induction of cell aging has been studied in detail, but the effect of antibacterial antibiotics on this process is still essentially unknown. This review aims to draw researchers' attention to the possibility of accelerated cellular aging induced by common antibacterial antibiotics and to discuss the potential mechanisms behind this phenomenon.

About the authors

R. A Zinovkin

A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University

Email: roman.zinovkin@gmail.com
Moscow, Russia; Moscow, Russia

N. D Kondratenko

A. N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University

Moscow, Russia; Moscow, Russia

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