Evaluation of the effectiveness of natural enterosorbents in removing residual amounts of antibiotics
- Authors: Kataeva N.N.1, Sarkisyan N.G.1,2, Shardina L.A.1, Kushnareva D.V.1, Arama S.M.1
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Affiliations:
- Ural State Medical University, Ministry of Health of Russia
- Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
- Issue: Vol 35, No 7 (2024)
- Pages: 50-52
- Section: Pharmacology
- URL: https://ogarev-online.ru/0236-3054/article/view/261017
- DOI: https://doi.org/10.29296/25877305-2024-07-08
- ID: 261017
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Abstract
The toxic effect of antibiotics on the human body is due, among other things, to their accumulation in vivo during long-term use or at high dosages. Removal of residual amounts of antibiotics and their metabolic products after a course of therapy is possible with the help of sorbents, while natural enterosorbents have a number of advantages over synthetic ones.
Purpose. To identify the most effective type of natural enterosorbent for the removal of cephalosporin antibiotics using ceftriaxone as an example.
Material and methods. During the work, a series of aqueous solutions of ceftriaxone sodium salt with concentrations of 0.54•10-3 mol/l was prepared; 0.90•10-3 mol/l; 1.44•10-3 mol/l; 2.70•10-3 mol/l; 4.51•10-3 mol/l and mixed with equal amounts of adsorbents such as zosterol, povidone, apple and citrus pectins. The specific adsorption of the antibiotic was determined by the difference in solution concentrations before and after adsorption using conductometry.
Results. Based on experimental data, adsorption isotherms of ceftriaxone on four enterosorbents were constructed. The graphs determined the concentrations of the antibiotic at which the maximum saturation of the corresponding adsorbent occurs: for zosterol – 0.54•10-3 mol/l, for apple pectin – 0.9•10-3 mol/l, for citrus pectin – 2.7•10-3 mol/l, on the surface of povidone the maximum saturation is not reached even at a maximum antibiotic concentration of 4.5•10-3 mol/l.
Conclusion. All studied natural sorbents are capable of adsorbing ceftriaxone and, as a result, removing it from the body. The most effective sorbent in relation to the antibiotic under study is povidone.
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##article.viewOnOriginalSite##About the authors
N. N. Kataeva
Ural State Medical University, Ministry of Health of Russia
Author for correspondence.
Email: sopenko2011@mail.ru
Associate Professor, Candidate of Chemical Sciences
Russian Federation, YekaterinburgN. G. Sarkisyan
Ural State Medical University, Ministry of Health of Russia; Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Sciences
Email: kataeva.nn@mail.ru
Professor, MD
Russian Federation, Yekaterinburg; YekaterinburgL. A. Shardina
Ural State Medical University, Ministry of Health of Russia
Email: kataeva.nn@mail.ru
Professor, MD
Russian Federation, YekaterinburgD. V. Kushnareva
Ural State Medical University, Ministry of Health of Russia
Email: kataeva.nn@mail.ru
Russian Federation, Yekaterinburg
S. M. Arama
Ural State Medical University, Ministry of Health of Russia
Email: kataeva.nn@mail.ru
Russian Federation, Yekaterinburg
References
- Машковский М.Д. Лекарственные средства. Новая Волна, 2012; 1216. [Mashkovskiy M.D. Lekarstvennye sredstva. Novaya Volna, 2012; 1216 (in Russ.)].
- Ярушина Я.Н. Clostridium difficile инфекция – новая междисциплинарная проблема. Уральский медицинский журнал. 2016; 8 (141): 125–31 [Yarushina Ya.N. Clostridium difficile infection - a new interdisciplinary problem. Ural Medical Journal. 2016; 8(141): 125-131 (In Russ.)]
- Буеверов А.О., Богомолов П.О., Буеверова Е.Л. Гепатотоксичность антибактериальных препаратов в терапевтической практике. Клиническая микробиология и антимикробная химиотерапия. 2015; 17 (3): 207–16 [Bueverov A.O., Bogomolov P.O., Bueverova E.L. Hepatotoxicity of Antibacterial Agents in Clinical Practice. Clinical microbiology and antimicrobial chemotherapy. 2015; 17(3): 207–16 (in Russ.)].
- Галеева Ж.А., Зырянов С.К. Кардиотоксичность макролидных антибиотиков. Клиническая микробиология и антимикробная химиотерапия. 2015; 17 (4): 262–6 [Galeeva G.A., Zirjanov S.K. Kardiotoksichnost makrolidnich antibiotikov. Clinical microbiology and antimicrobial chemotherapy. 2015; 17 (4): 262–6 (in Russ.)].
- Усенко Д.В. Антибиотик-индуцированные изменения микробиома желудочно-кишечного тракта и их коррекция. РМЖ. 2018; 26 (2-2): 96–9 [Usenko D.V. Antibiotic-induced changes in the microbiota of the gastrointestinal tract and their correction. RMJ. 2018; 26 (2-2): 96–9 (in Russ.)].
- Постников С.С. Токсические эффекты антибиотиков. Педиатрия. Журнал им. Г.Н. Сперанского. 2008; 87 (2): 21 [Postnikov S.S. Toxic effects of antibiotics. Pediatria n.a. G.N. Speransky. 2008; 87 (2): 21 (in Russ.)].
- Клындюк А.И. Поверхностные явления и дисперсные системы. Минск: БГТУ, 2011; 55 [Klyndyuk A.I. Poverkhnostnye yavleniya i dispersnye sistemy. Minsk: BGTU Publ., 2011; 55 (in Russ.)].
- Кокорина М.Л., Есаулкова А.Н., Жиляков А.А. и др. Изучение способности цефтриаксона к адсорбции и комплексообразованию в условиях in vitro. Современные достижения химико-биологических наук в профилактической и клинической медицине: Сб. науч. тр. 3-й междунар. конф, посвящ. 110-летию доктора биологических наук, профессора А. П. Бресткина, Санкт-Петербург, 01-02 декабря 2022 года. Том Часть 1. Санкт-Петербург: СЗГМУ им. И.И. Мечникова. 2022; с. 82–8 [Kokorina M.L., Esaulkova A.N., Zhilyakov A.A. et al. Izuchenie sposobnosti tseftriaksona k adsorbtsii i kompleksoobrazovaniyu v usloviyakh in vitro. Sovremennye dostizheniya khimiko-biologicheskikh nauk v profilakticheskoi i klinicheskoi meditsine: Sb. nauch. tr. 3-i mezhdunar. konf, posvyashch. 110-letiyu doktora biologicheskikh nauk, professora A. P. Brestkina, Sankt-Peterburg, 01-02 dekabrya 2022 goda. Tom Chast' 1. Saint Petersburg: SZGMU im. I.I. Mechnikova. 2022; рр. 82–8 (in Russ.)].
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