Synthesis and Cardiotropic Activity of 1-(Methoxybenzyl)-4-{2-[(Methoxybenzyl)-Amino]Ethyl}Piperazines
- 作者: Mokrov G.V.1, Likhosherstov A.M.1, Barchukov V.V.1, Stolyaruk V.N.1, Tsorin I.B.1, Vititnova M.B.1, Rebeko A.G.1, Kryzhanovskii S.A.1, Gudasheva T.A.1
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隶属关系:
- V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
- 期: 卷 53, 编号 9 (2019)
- 页面: 786-791
- 栏目: Search for New Drugs
- URL: https://ogarev-online.ru/0091-150X/article/view/246009
- DOI: https://doi.org/10.1007/s11094-019-02080-2
- ID: 246009
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详细
A group of new 1-(methoxybenzyl)-4-{2-[(methoxybenzyl)amino]ethyl}piperazines (1) were synthesized. The relationship of the structure of the triazaalkane linker and the cardiotropic activity in a series of these compounds was compared with that of previously studied linear and cyclic methoxyphenyltriazaalkanes. The most active compound in the group was 1e (1-(3,4,5-trimethoxybenzyl)-4-{2-[(3,4,5-trimethoxybenzyl)amino] ethyl}piperazine trihydrochloride) with statistically significant antiarrhythmic activity in aconitine and CaCl2 arrhythmia models.
作者简介
G. Mokrov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
编辑信件的主要联系方式.
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
A. Likhosherstov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
V. Barchukov
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
V. Stolyaruk
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
I. Tsorin
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
M. Vititnova
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
A. Rebeko
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
S. Kryzhanovskii
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
T. Gudasheva
V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315
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