Synthesis and Cardiotropic Activity of 1-(Methoxybenzyl)-4-{2-[(Methoxybenzyl)-Amino]Ethyl}Piperazines


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详细

A group of new 1-(methoxybenzyl)-4-{2-[(methoxybenzyl)amino]ethyl}piperazines (1) were synthesized. The relationship of the structure of the triazaalkane linker and the cardiotropic activity in a series of these compounds was compared with that of previously studied linear and cyclic methoxyphenyltriazaalkanes. The most active compound in the group was 1e (1-(3,4,5-trimethoxybenzyl)-4-{2-[(3,4,5-trimethoxybenzyl)amino] ethyl}piperazine trihydrochloride) with statistically significant antiarrhythmic activity in aconitine and CaCl2 arrhythmia models.

作者简介

G. Mokrov

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

编辑信件的主要联系方式.
Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

A. Likhosherstov

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

V. Barchukov

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

V. Stolyaruk

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

I. Tsorin

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

M. Vititnova

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

A. Rebeko

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

S. Kryzhanovskii

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

T. Gudasheva

V. V. Zakusov State Institute of Pharmacology, Russian Academy of Medical Sciences

Email: g.mokrov@gmail.come
俄罗斯联邦, 8 Baltiiskaya St., Moscow, 125315

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