Synthesis and Antioxidant and Anti-Influenza Activity of Aminomethanesulfonic Acids


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Aminomethanesulfonic acid (I) and its N-methyl- (II), N-(2-hydroxy)ethyl- (III), N-(tert-butyl)- (IV), N-benzyl- (V), and 4-(N-phenylaminomethyl)phenyl- (VI) derivatives (V and VI not previously reported) were synthesized and characterized by elemental analysis and IR and mass spectroscopy. The in vitro antioxidant activities of aminomethanesulfonic acids I-VI were found to be comparatively weak. Compounds IV and V suppressed statistically significantly reproduction of influenza virus strains A/Hong Kong/1/68 (H3N2) and A/PR/8/34 (H1N1) in chorioallantoic membrane tissue culture.

作者简介

R. Khoma

Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine; I. I. Mechnikov Odessa National University

编辑信件的主要联系方式.
Email: rek@onu.edu.ua
乌克兰, Odessa, 65082; Odessa

V. Gelmboldt

I. I. Mechnikov Odessa National University

Email: rek@onu.edu.ua
乌克兰, Odessa

A. Énnan

Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine

Email: rek@onu.edu.ua
乌克兰, Odessa, 65082

T. Gridina

Odessa National Medical University; Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine

Email: rek@onu.edu.ua
乌克兰, Odessa, 65082; Odessa, 65082

A. Fedchuk

Odessa Research Center Biomedical Testing of Food and Drugs; Physical-Chemical Institute for Environmental and Human Protection, Ministry of Education and Science and National Academy of Sciences of Ukraine

Email: rek@onu.edu.ua
乌克兰, Odessa, 65003; Odessa, 65082

V. Lozitsky

Odessa Research Center Biomedical Testing of Food and Drugs

Email: rek@onu.edu.ua
乌克兰, Odessa, 65003

I. Rakipov

A. V. Bogatsky Physical-Chemical Institute, National Academy of Sciences of Ukraine

Email: rek@onu.edu.ua
乌克兰, Odessa

A. Vladyka

Odessa National Medical University

Email: rek@onu.edu.ua
乌克兰, Odessa, 65082

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