Quantitative Determination of Ivabradine and Its N-Demethylated Metabolite in Volunteer Blood and Urine

L. A. Smirnova; B. E. Tolkachev; A. F. Ryabukha; E. A. Suchkov; K. A. Kuznetsov; O. V. Magnitskaya; V. I. Petrov

doi:10.1007/s11094-019-01992-3

Quantitative Determination of Ivabradine and Its N-Demethylated Metabolite in Volunteer Blood and Urine

作者: Smirnova L.A.¹^,2, Tolkachev B.E.¹^,2, Ryabukha A.F.¹^,2, Suchkov E.A.¹^,2, Kuznetsov K.A.¹^,2, Magnitskaya O.V.¹, Petrov V.I.¹
隶属关系:
1. Volgograd State Medical University
2. Volgograd Medical Research Center
期: 卷 53, 编号 3 (2019)
页面: 275-278
栏目: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245730
DOI: https://doi.org/10.1007/s11094-019-01992-3
ID: 245730

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An HPLC method was developed for quantitative determination and pharmacokinetic analysis of ivabradine and its N-demethylated metabolite using the new internal standard domperidone. The method is highly sensitive and selective and can be used in bioassays. The sample preparation procedure was optimized and did not significantly influence the standard error of the quantitative chromatographic method.