Email this article Quantitative Determination of Ivabradine and Its N-Demethylated Metabolite in Volunteer Blood and Urine
- Authors: Smirnova L.A.1,2, Tolkachev B.E.1,2, Ryabukha A.F.1,2, Suchkov E.A.1,2, Kuznetsov K.A.1,2, Magnitskaya O.V.1, Petrov V.I.1
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Affiliations:
- Volgograd State Medical University
- Volgograd Medical Research Center
- Issue: Vol 53, No 3 (2019)
- Pages: 275-278
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245730
- DOI: https://doi.org/10.1007/s11094-019-01992-3
- ID: 245730
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Abstract
An HPLC method was developed for quantitative determination and pharmacokinetic analysis of ivabradine and its N-demethylated metabolite using the new internal standard domperidone. The method is highly sensitive and selective and can be used in bioassays. The sample preparation procedure was optimized and did not significantly influence the standard error of the quantitative chromatographic method.
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About the authors
L. A. Smirnova
Volgograd State Medical University; Volgograd Medical Research Center
Author for correspondence.
Email: post@volgmed.ru
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
B. E. Tolkachev
Volgograd State Medical University; Volgograd Medical Research Center
Email: post@volgmed.ru
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
A. F. Ryabukha
Volgograd State Medical University; Volgograd Medical Research Center
Email: post@volgmed.ru
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
E. A. Suchkov
Volgograd State Medical University; Volgograd Medical Research Center
Email: post@volgmed.ru
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
K. A. Kuznetsov
Volgograd State Medical University; Volgograd Medical Research Center
Email: post@volgmed.ru
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131; 1 Pavshchikh Bortsov Sq., Volgograd, 400131
O. V. Magnitskaya
Volgograd State Medical University
Email: post@volgmed.ru
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131
V. I. Petrov
Volgograd State Medical University
Email: post@volgmed.ru
Russian Federation, 1 Pavshchikh Bortsov Sq., Volgograd, 400131
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