Synthesis and Molecular Structure of Ethyl-4-Hydroxy-1-Phenyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylate
- 作者: Ukrainets I.V.1, Petrushova L.A.1, Sim G.2, Grinevich L.A.1
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隶属关系:
- National University of Pharmacy
- Far Eastern State Medical University
- 期: 卷 51, 编号 6 (2017)
- 页面: 482-485
- 栏目: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244664
- DOI: https://doi.org/10.1007/s11094-017-1638-8
- ID: 244664
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详细
Methyl-4-hydroxy-1-phenyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate was found to undergo transesterification even during crystallization from EtOH to convert into the corresponding ethyl ester. The molecular structure of the obtained compound was studied. In particular, PMR spectroscopy and x-ray crystal structure analysis established that the 1-N-phenyl substituent was situated in solution at an angle of ~60° to the plane formed by the aminophenylcarbinol fragment of the 2,1-benzothiazine whereas this angle increased to 80° in the crystal because of packing effects.
作者简介
I. Ukrainets
National University of Pharmacy
Email: chem@folium.ru
乌克兰, Kharkiv, 61000
L. Petrushova
National University of Pharmacy
Email: chem@folium.ru
乌克兰, Kharkiv, 61000
G. Sim
Far Eastern State Medical University
Email: chem@folium.ru
俄罗斯联邦, Khabarovsk, 680000
L. Grinevich
National University of Pharmacy
Email: chem@folium.ru
乌克兰, Kharkiv, 61000
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