Joint Mechanical Processing of a Drug Substance with Enterosorbent

N. S. Ivanova; T. S. Pak; É. L. Kristalovich; D. B. Takhtaganova

doi:10.1007/s11094-019-01942-z

Joint Mechanical Processing of a Drug Substance with Enterosorbent

Авторы: Ivanova N.S.¹, Pak T.S.¹, Kristalovich É.L.², Takhtaganova D.B.²
Учреждения:
1. Pskov State University
2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Выпуск: Том 52, № 12 (2019)
Страницы: 1007-1010
Раздел: Article
URL: https://ogarev-online.ru/0091-150X/article/view/245579
DOI: https://doi.org/10.1007/s11094-019-01942-z
ID: 245579

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Аннотация

A selective enterosorbent (ES) based on natural silk fibroin with detoxification properties superior to those of traditional carbon sorbents (SKN-2K, SKN-4M) was proposed. The ES could be used as a matrix for drugs and a platform for new dosage forms to enhance the sanitizing effect of the proposed ES. Inclusion complexes of the ES with benzimidazolyl-2-methylcarbamate hydrochloride (I) were obtained and investigated. H-bonds were shown to form during the reaction of ES with I.