Email this article Joint Mechanical Processing of a Drug Substance with Enterosorbent
- Authors: Ivanova N.S.1, Pak T.S.1, Kristalovich É.L.2, Takhtaganova D.B.2
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Affiliations:
- Pskov State University
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Issue: Vol 52, No 12 (2019)
- Pages: 1007-1010
- Section: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/245579
- DOI: https://doi.org/10.1007/s11094-019-01942-z
- ID: 245579
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Abstract
A selective enterosorbent (ES) based on natural silk fibroin with detoxification properties superior to those of traditional carbon sorbents (SKN-2K, SKN-4M) was proposed. The ES could be used as a matrix for drugs and a platform for new dosage forms to enhance the sanitizing effect of the proposed ES. Inclusion complexes of the ES with benzimidazolyl-2-methylcarbamate hydrochloride (I) were obtained and investigated. H-bonds were shown to form during the reaction of ES with I.
About the authors
N. S. Ivanova
Pskov State University
Author for correspondence.
Email: zavelej89@mail.ru
Russian Federation, Pskov
T. S. Pak
Pskov State University
Email: zavelej89@mail.ru
Russian Federation, Pskov
É. L. Kristalovich
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavelej89@mail.ru
Russian Federation, Moscow, 119991
D. B. Takhtaganova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavelej89@mail.ru
Russian Federation, Moscow, 119991
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