Отправить статью по E-mail HPLC-MS/MS Method for Determining Dabigatran in Human Blood Serum
- Авторы: Rodina T.A.1,2, Mel’nikov E.S.2,3, Aksenov A.A.1,3, Belkov S.A.1,2,3, Sokolov A.V.1,3, Prokof’ev A.B.1,2,3, Ramenskaya G.V.1,3
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Учреждения:
- Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
- I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
- I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
- Выпуск: Том 51, № 12 (2018)
- Страницы: 1129-1137
- Раздел: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244948
- DOI: https://doi.org/10.1007/s11094-018-1753-1
- ID: 244948
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Аннотация
An HPLC-MS/MS method for determining dabigatran in human blood serum was developed. Samples were prepared by precipitation of proteins using MeOH followed by centrifugation and dilution with deionized H2O. The developed method had a simple sample-preparation procedure, short analysis time, and wide analytical range (from 1 to 1,000 ng/mL). This method was suitable for routine bioanalytical studies, in particular, therapeutic drug monitoring.
Об авторах
T. Rodina
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Россия, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240
E. Mel’nikov
I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Россия, 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
A. Aksenov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Россия, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
S. Belkov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Россия, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
A. Sokolov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Россия, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
A. Prokof’ev
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Россия, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
G. Ramenskaya
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Россия, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
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