Мақаланы E-mail арқылы жіберу HPLC-MS/MS Method for Determining Dabigatran in Human Blood Serum
- Авторлар: Rodina T.A.1,2, Mel’nikov E.S.2,3, Aksenov A.A.1,3, Belkov S.A.1,2,3, Sokolov A.V.1,3, Prokof’ev A.B.1,2,3, Ramenskaya G.V.1,3
-
Мекемелер:
- Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation
- I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
- I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
- Шығарылым: Том 51, № 12 (2018)
- Беттер: 1129-1137
- Бөлім: Article
- URL: https://ogarev-online.ru/0091-150X/article/view/244948
- DOI: https://doi.org/10.1007/s11094-018-1753-1
- ID: 244948
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Тек жазылушылар үшін
Аннотация
An HPLC-MS/MS method for determining dabigatran in human blood serum was developed. Samples were prepared by precipitation of proteins using MeOH followed by centrifugation and dilution with deionized H2O. The developed method had a simple sample-preparation procedure, short analysis time, and wide analytical range (from 1 to 1,000 ng/mL). This method was suitable for routine bioanalytical studies, in particular, therapeutic drug monitoring.
Авторлар туралы
T. Rodina
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240
E. Mel’nikov
I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Ресей, 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
A. Aksenov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
S. Belkov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
A. Sokolov
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
A. Prokof’ev
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. V. Davydovsky Municipal Clinical Hospital, Moscow City Department of Health; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051; 11 Yauzskaya St., Moscow, 109240; 8/2 Trubetskaya St., Moscow, 119991
G. Ramenskaya
Scientific Center for Expert Evaluation of Medical Products, Ministry of Health of the Russian Federation; I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University)
Email: chem@folium.ru
Ресей, 8/2 Petrovskii Blvd., Moscow, 127051; 8/2 Trubetskaya St., Moscow, 119991
Қосымша файлдар
